|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL-28B rs12979860 C/T polymorphism is associated with a greater likelihood of HCV persistence, particularly in HCV genotypes 1 and 4.
|
21647799 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients carrying both CC(rs12979860) and TT(rs8099917) genotypes achieved lower levels of HCV RNA at week 4 than those with CT or TT at rs12979860 and TT(rs8099917) (P = 0.0004).
|
21692944 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we investigated the relative genetic contributions of the CCR5Δ32 deletion and the IL28B rs12979860 polymorphisms to spontaneous clearance of hepatitis C in a single-source outbreak.
|
21703201 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have identified two host single-nucleotide polymorphisms (SNPs) near the IL28B gene (rs12979860 C/T and rs8099917 T/G) that are associated with sustained virological response in patients infected with the hepatitis C virus.
|
21704279 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the rs12979860 polymorphism is associated with spontaneous clearance of HCV in HIV-1 Brazilian infected patients.
|
21790472 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients.
|
21813376 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Rs8099917 TT and rs12979860 CC genotypes were associated with SVR in HCV genotype 1 patients [odds ratio=2.60 (1.36-5.00), P=0.004 and odds ratio=3.30 (1.58-6.90), P=0.03 respectively].
|
21900787 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL28B rs12979860 SNP may have an added value in the treatment algorithm of HCV-4 patients because it is the strongest predictor of an SVR to PegIFN/Rbv therapy.
|
21932415 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance).
|
21933876 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study clearly shows an association between first-phase viral load decrease and the IL28B rs12979860 polymorphism in chronic HCV-infected patients.
|
21974859 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evidence that a supra-additive rs12979860-based model best fits the association of IL28B-genotype with HCV clearance may improve clinical prediction models and foster a better understanding of functional mechanisms underlying this association.
|
22013224 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In multivariate analysis, females with the favorable genotype for rs12979860 (CC) had an increased odds to spontaneously clear HCV infection (adjusted OR 6.62, 95% 2.69-26.13), whereas females with the unfavorable genotype were as likely as men with the favorable and unfavorable genotype to clear HCV.
|
22110669 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that rs12979860 does not have such a strong effect in hepatitis B compared to hepatitis C.
|
22239156 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNP, rs8099917, rs12979860) near the IL28B gene have been illustrated as outcome predictors of hepatitis C virus (HCV) treatment with pegylated interferon/ribavirin.
|
22257210 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Early viral load and recipient interleukin-28B rs12979860 genotype are predictors of the progression of hepatitis C after liver transplantation.
|
22298465 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results demonstrate that rs12979860, compared to rs8099917, may be a better predictor of response to the peg-IFN/RBV treatment among HCV/HIV-1 coinfected patients.
|
22328925 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association between the other four IL28B SNPs including rs12979860 and spontaneous HCV clearance was found.
|
22329371 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In unadjusted analyses, higher levels were found with older age, male gender, African-American ancestry, hepatitis B virus infection, HIV-1 infection, and IL28B rs12979860-CC genotype; compared to participants infected with HCV genotype 1, HCV RNA was lower in participants with genotypes 3 or 4.
|
22331649 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One hundred sixty-seven HCV-positive patients after LT were genotyped for IL28B (C→T; rs12979860).
|
22411462 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Point mutations in the coding region of the interleukin 28 gene (rs12979860) have recently been identified for predicting the outcome of treatment of hepatitis C virus infection.
|
22412970 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In HCV-G1, interferon sensitivity is characterised by low LVP ratios and low apoE levels in addition to higher LDL-C and IL28B rs12979860 CC.
|
22414761 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the interaction between IL-28B rs12979860 T/T genotype and low serum cholesterol concentration is an independent predictor of a worse disease course among patients infected with HCV with normal or near-normal transaminases.
|
22431022 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Linkage disequilibrium between two IL28B polymorphisms at rs8099917 and rs12979860 is strong in Japanese HCV patients, but there are some discrepancies between the two sets of genotypes.
|
22438096 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is known to predict the outcome of antiviral therapy in hepatitis C. In addition to its interferon-like and antiviral functions, IL-28B possesses the ability to modulate CD8 T cells function.
|
22495472 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B rs12979860 CC and rs8099917 TT are strong SVR predictors for PEG IFN-α/ribavirin-treated HCV-1 patients, regardless of ethnicity.
|
22591106 |
2012 |