|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between viral load and demographic, obstetrical, HCV risk factors, and interleukin-28B gene (IL28B) polymorphism (rs12979860) were assessed.
|
28903504 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylation was strongly associated with rs12979860 allele status whether adjusting for HCV status (r=65.0%, 95% CI: [60.2%, 69.5%]), or not (r=64.4%), both with P<2.2×10<sup>-16</sup> .
|
27925355 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition to rs4803217, also single nucleotide polymorphisms (SNPs) (rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed.
|
28638221 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown.
|
29040985 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to determine whether IL28B rs12979860 polymorphism is also associated with development of hepatocellular carcinoma both in chronic HCV infection and in non-viral-related cirrhosis.
|
27083168 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV.
|
27183918 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry.
|
26973228 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using linear regression, after adjusting for sex, age, infection duration, symptomatic infection, HIV co-infection, interferon-lambda rs12979860 genotype, HCV genotype, and assay run, higher ALT levels (β = 0.20; 95 % CI: 0.07, 0.32; P = 0.002) and HCV RNA levels >400,000 IU/mL (vs. <8,500 IU/mL; β = 0.16; 95 % CI: 0.03, 0.28; P = 0.014) were independently associated with higher IP-10 levels.
|
26911712 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC).
|
27035616 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed 230 TM patients with HCV infection (mean age 36.0±6.3 years; 59.1% genotype 1; 32.2% genotype 2; 3.4% genotype 3; and 5.3% genotype 4; 28.7% carried CC allele of rs12979860 in IL28B locus; 79.6% had chronic hepatitis and 20.4% cirrhosis; 63.5% naive and 36.5% previously treated with interferon alone) treated in 14 Italian centers.
|
27012446 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.
|
27275739 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, T2D patients with CT/TT rs12979860 HCV risk genotypes possessed significantly higher HbA1c levels than CC carriers (p=0.04).
|
27664841 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One hundred eight HCV chronically infected patients initiating treatment with pegylated IFN plus ribavirin for 48 wk were tested for baseline substitutions at codons 70 and 91 of the viral core protein (BigDye Terminator vers.3.1, Applied Biosystems,) and for genetic polymorphisms in host <i>IL28B</i> gene rs12979860 (Custom TaqMan 5' allelic discrimination assay; Applied Biosystems).
|
27729747 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Favourable genotypes of IFNL3 polymorphism CC for rs12979860 and TT for rs8099917 are strongly associated with the interferon/ribavirin treatment outcome in hepatitis C virus (HCV) patients with genotypes 1 and 4.
|
27498543 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This same variant is associated with treatment-induced clearance in patients with genotype 1b, but not 2a. ss469415590 (or rs12979860) genotyping should be considered for patients with HCV genotype 1b and high viral load when making a choice between standard dual therapy and an IFN-free direct-acting antiviral regimen.
|
26820907 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL28B rs12979860 host genotype (CC vs non-CC), cirrhosis status (compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype (GT1a vs GT1b).
|
27022224 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphism of the IL28B gene (rs8099917, rs12979860) and virological response of Pakistani hepatitis C virus genotype 3 patients to pegylated interferon therapy.
|
25462177 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype-genotype interaction between IL-28B rs12979860 and CTLA-4 rs3087243 was found to be significantly associated with increased susceptibility to HCV infection (adjusted OR=1.509, P=0.005).
|
26079279 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, rs12979860 (CC) and ss469415590 (TT/TT) genotypes were associated with higher SVR rated only in patients with HCV-1.
|
25938236 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CC genotype of IL-28B SNP rs12979860 is an independent predictive factor for SVR in chronic HCV-infected patients in Pakistan.
|
25708904 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The patient had the IL-28B gene polymorphism rs12979860 CT genotype, which is associated not only with antiviral therapy response but also with diabetes risk after liver transplantation for hepatitis C.
|
25204264 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant').
|
26186989 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interleukin-28B (IL28B) gene contains a single-nucleotide polymorphism at location rs12979860 that affects both the natural history of hepatitis C virus infection and the patient's response to treatment, particularly interferon-based regimens with or without protease inhibitors.
|
25897598 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping IL28B SNP rs12979860 is useful to predict the response to a standard regimen with PegIFN-α/RVB, especially in those infected with HCV genotype 1.
|
26189761 |
2015 |