|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension.
|
31242870 |
2019 |
|
rs2681472
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the associations of <i>ATP2B1</i> rs2681472 and <i>CACNB2</i> rs12258967 gene polymorphisms with high blood pressure (HBP) among Lithuanian children and adolescents aged 12-15 years.
|
29982197 |
2018 |
|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant.
|
24642721 |
2014 |
|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |
|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Association of allelic variants in rs2681472 and rs2681492 with hypertension, rs987237 and rs7826222 with waist circumference and rs864745, rs7578597 and rs2943641 with diabetes were not significant.
|
23036851 |
2013 |
|
rs2681472
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The results suggested that rs2681472 was significantly associated with hypertension risk in East Asians (OR = 1.18, 95% CI 1.10-1.27, p = 0.000).
|
22229515 |
2012 |
|
rs2681472
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association study of blood pressure and hypertension.
|
19430479 |
2009 |
|
rs2681472
|
|
A |
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association study of blood pressure and hypertension.
|
19430479 |
2009 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes.
|
31513605 |
2019 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension.
|
31242870 |
2019 |
|
rs17249754
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K.
|
28934190 |
2017 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
That is, carriers with ATP2B1 rs17249754 homozygote mutant allele may be at higher risk of hypertension, when they consume excessive sodium intake.
|
27149052 |
2016 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The MDR analysis demonstrated that the interaction of rs2070759, rs17249754, TC, TG, and BMI increased the susceptibility to hypertension.
|
26933664 |
2016 |
|
rs17249754
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
|
23759979 |
2014 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004).
|
23591986 |
2013 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
All studies evaluating the association between rs2681472 (rs17249754 or rs11105378) and hypertension risk in East Asians were included.
|
22229515 |
2012 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
rs17249754
|
|
|
0.800 |
GeneticVariation |
BEFREE |
An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts.
|
19960030 |
2010 |
|
rs1401982
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
rs2681492
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |