|
rs4606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether distribution of three putative regulatory SNPs rs13430086, rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2, respectively, that have been associated with hypertension and regulation of trophoblast invasion differ between women with PE and control group.
|
29593124 |
2018 |
|
rs4606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs4606 3' UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia.
|
27558088 |
2016 |
|
rs4606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery.
|
24593135 |
2014 |
|
rs4606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene (GNB3) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (AGTR1) 3'UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (RGS2) 3'UTR C1114G polymorphism (rs4606).
|
23339167 |
2013 |
|
rs200339834
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, our data are consistent with the notion that a R44H missense mutation in human RGS2 produces a hypomorphic allele that may lead to altered receptor-mediated G(q) inhibition and contribute to the development of hypertension in affected subjects.
|
18230714 |
2008 |
|
rs200339834
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Six out of seven individuals with the R44H mutation, which occurs in the amphipathic alpha-helical domain of RGS2, had hypertension.
|
16003176 |
2005 |
|
rs2746071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to characterize the association of clinical and genetic risk factors such as: ACE genotype (rs17997552, rs1800764, rs4459609) and RGS2 (rs2746071) with the development of hypertension (HT) and non-dipping phenomenon in patients with type 1 diabetes mellitus (T1DM).
|
24562335 |
2014 |
|
rs74466425
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension.
|
20662725 |
2010 |
|
rs77790369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension.
|
20662725 |
2010 |
|
rs34717272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single locus analyses showed significant association of the alleles of RGS2-rs34717272 with hypertension (original P of chi2 test=0.005; P value of permutation=0.019).
|
18496125 |
2008 |