|
rs4539
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The rs4539 (AA), H1, H2, and H3 are genetic predictors for postoperative persistence of hypertension for Chinese patients treated by adrenalectomy with APA.
|
20708777 |
2010 |
|
rs4539
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the -344T/C, K173R and intron-2 conversion polymorphisms of CYP11B2 for an association with hypertension in highlanders accustomed to a high salt intake.
|
15643128 |
2005 |
|
rs4539
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The objective of this study was to investigate the association of polymorphisms in the aldosterone synthase gene CYP11B2 (-344T/C, Lys173/Arg, and an intronic conversion [IC]) with stage-2 hypertension in northern Han Chinese.
|
15479186 |
2004 |
|
rs4539
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To compare the frequency of three variants (-344C/T, intron 2 conversion, and the K173R polymorphism) of the aldosterone synthase gene in blacks and whites, and to determine any association of the variants with hypertension.
|
12544440 |
2003 |
|
rs4539
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension.
|
10720581 |
2000 |
|
rs1799998
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We did not observe associations between hypertension and rs1799752 (<i>P</i>=0.422), rs699 (<i>P</i>=0.36), rs5186 (<i>P</i>=0.49), and rs1799998 (<i>P</i>=0.71).
|
31511791 |
2019 |
|
rs1799998
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The CC of rs4994 and CC or C allele of rs1799998 might be protective genetic factors of hypertension.
|
25099490 |
2014 |
|
rs1799998
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Hypertension association reached genome-wide significance for the two variants, specifically, P=7.3 × 10(-10) for AGT rs699 and P=3.9 × 10(-8) for CYP11B2 rs1799998.
|
22456346 |
2012 |
|
rs1799998
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present case-control study we investigated the association of -344C/T (rs1799998) [corrected] polymorphism in the promoter region of the human aldosterone (CYP11B2) gene with genetic predisposition to hypertension, ischemic stroke and stroke subtypes classified according to TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification.
|
20598712 |
2010 |
|
rs542092383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AG genotype frequency of SNP rs542092383 was significantly associated with an increased risk of hypertension (OR 4.513, 95% CI 1.426-14.287, P = .010).
|
28953657 |
2017 |
|
rs10086846
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension.
|
24015270 |
2013 |
|
rs3802230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension.
|
24015270 |
2013 |
|
rs4536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the Hani minority, rs4536 was significantly associated with hypertension, after Bonferroni correction.
|
21127960 |
2011 |
|
rs5310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to these polymorphisms, the T(-344)C polymorphism in the promoter of the aldosterone synthase gene (CYP11B2) and the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) are considered candidates for the genetic risk of salt-sensitive hypertension.
|
12924618 |
2003 |