Gene: GCKR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1260326
rs1260326
GCKR
0.820 GeneticVariation BEFREE Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively. 26578543

2016
dbSNP: rs1260326
rs1260326
GCKR
0.820 GeneticVariation GWASDB Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. 23505323

2013
dbSNP: rs1260326
rs1260326
GCKR
0.820 GeneticVariation BEFREE Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults. 22105854

2012
dbSNP: rs1260326
rs1260326
GCKR
T 0.820 GeneticVariation GWASDB Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596

2010
dbSNP: rs1260326
rs1260326
GCKR
T 0.820 GeneticVariation GWASCAT Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596

2010
dbSNP: rs780094
rs780094
GCKR
T 0.730 GeneticVariation GWASCAT A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. 27599772

2017
dbSNP: rs780094
rs780094
GCKR
0.730 GeneticVariation BEFREE The T2D risk alleles of rs972283 near KLF14 and rs11634397 near ZFAND6 were associated with a higher risk for elevated triglycerides (rs972283: 1.11 (1.02, 1.24), P = 1.46 × 10-2; rs11634397: 1.14 (1.00, 1.29), P = 4.66 × 10-2), while the T2D risk alleles of rs780094 in GCKR and rs7903146 in TCF7L2 were related to a lower risk of elevated triglycerides (rs780094: 0.86 (0.80, 0.93), P = 1.35 × 10-4; rs7903146: 0.82 (0.69, 0.98), P = 3.18 × 10-2). 26599349

2015
dbSNP: rs780094
rs780094
GCKR
0.730 GeneticVariation BEFREE GCKR rs780094 was also associated with decreased plasma glucose, and increased triglycerides in the patient and control groups. 24785259

2014
dbSNP: rs780094
rs780094
GCKR
0.730 GeneticVariation BEFREE The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. 20574426

2010
dbSNP: rs780093
rs780093
GCKR
0.700 GeneticVariation GWASCAT A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. 27599772

2017