| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.810 | GeneticVariation | BEFREE | The significance of these results is amplified by studies suggesting that a single nucleotide polymorphism in IFNG-AS1, rs7134599, was associated with both subtypes of IBD patients independently of race. | 31545920 | 2020 |
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|
A | 0.810 | GeneticVariation | GWASDB | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. | 23128233 | 2012 |
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|
A | 0.810 | GeneticVariation | GWASCAT | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. | 23128233 | 2012 |
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|
0.700 | GeneticVariation | GWASCAT | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. | 28067908 | 2017 |
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|
0.700 | GeneticVariation | GWASCAT | Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. | 26192919 | 2015 |
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|
0.010 | GeneticVariation | BEFREE | Meta-analyses showed that polymorphisms in TLR2 (rs3804099, OR (95% CI) = 2.17 (1.35-3.47)], rs11938228 [OR = 0.64 (0.43-0.96)], TLR4 (rs5030728) [OR = 3.18 (1.63-6.21)], TLR9 (rs352139) [OR = 0.43 (0.21-0.88)], TNFRSF1A (rs4149570) [OR = 2.06 (1.02-4.17)], IFNG (rs2430561) [OR = 1.66 (1.05-2.63)], IL6 (rs10499563) [OR = 1.65 (1.04-2.63)] and IL1B (rs4848306) [OR = 1.88 (1.05-3.35)] were significantly associated with response among IBD patients using clinical response criteria. | 27417569 | 2016 |
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|
0.010 | GeneticVariation | BEFREE | This study reports the first association of IFNG rs1861494 T allele with enhanced IFN-γ secretion and known IBD clinical parameters indicative of more aggressive disease and serological markers associated with treatment resistance to anti-tumor necrosis factor therapy in patients with IBD. | 25171510 | 2014 |