|
rs1416580204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the three described polymorphisms, only the RAGE Gly82Ser genotype frequency was significantly increased in the group with advanced nephropathy (11%) defined by a chronic renal failure compared to the three others groups: no nephropathy, 5%; incipient (microalbuminuria) 5%; established (macroalbuminuria), 2%) (P=0.04).
|
15803111 |
2005 |
|
rs3743930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of our patients had amyloidosis but two with E148Q/E148Q had a family history of amyloidosis and one had rapidly progressive glomerulonephritis secondary to vasculitis, which progressed to chronic renal failure.
|
15458961 |
2005 |
|
rs515299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, a heterozygous mutation (causing an S890I change) in factor H of complement was found in the patient who developed chronic renal failure but not in her sister, who presented with exclusive neurologic symptoms.
|
15800115 |
2005 |
|
rs61752717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, 43 patients had a family history of chronic renal failure, and 15 (35%) were homozygous for M694V.
|
15942916 |
2005 |
|
rs5355
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In ESRD, the Leu554Phe polymorphism of E-selectin gene is associated with the severity of carotid atherosclerosis, suggesting that genetically-determined alterations in the E-selectin molecule may render ESRD patients with this gene variant particularly susceptible to the detrimental effects of inflammation on the arterial wall.
|
16554320 |
2006 |
|
rs121908525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, in this PH1 population, all bearing the I244T mutation, the development of end-stage renal disease was distinctive during late adolescence or adulthood.
|
16912707 |
2006 |
|
rs5370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no differences in ages at the time of ESRD in patients with different haplotypes in the endothelin promoter (T-1370G) in combination with 3A/4A or K198N polymorphisms.
|
16943682 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no evidence for survival bias due to C677T genotype in the ESRD cohort, or bias due to genetically determined accelerated progression to novel microalbuminuria in the controls.
|
17005529 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the relationship between carotid intima-media thickness (IMT) and three endothelial NO synthase (eNOS) polymorphisms (G894T, T-786C, and 27-bp repeat in intron 4) in an ethnically and geographically homogeneous group of 147 patients with ESRD.
|
17586410 |
2007 |
|
rs1033182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association with type 2 diabetes-ESRD was with rs1033182 in intron 2 (P = 0.013, admixture-adjusted P(a) = 0.021).
|
17327435 |
2007 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in MDR1 between ESRD patients and healthy controls in the Chinese population to determine whether the alteration of the P-gp function is associated with ESRD.
|
17376299 |
2007 |
|
rs10808565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further identified a common haplotype containing the C allele at rs10808565 and the A allele at rs13447075 that was associated with ESRD (P = 0.003).
|
17881614 |
2007 |
|
rs13447075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Markers rs13447075 (odds ratio [OR] 1.47 [95% CI 1.14-1.89] per copy of A allele; P = 0.003) and rs2648862 (2.66 [1.19-5.92] per copy of C allele; P = 0.008) were strongly associated with ESRD in analyses adjusting for age(2), age(3), duration of diabetes, and smoking status.
|
17881614 |
2007 |
|
rs1452199941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in MDR1 between ESRD patients and healthy controls in the Chinese population to determine whether the alteration of the P-gp function is associated with ESRD.
|
17376299 |
2007 |
|
rs1709183
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two intron 2 SNPs, rs2431260 (P = 0.015) and rs1709183 (P = 0.019), and a four-SNP haplotype containing these SNPs (P = 0.033) were associated with type 2 diabetes and/or ESRD.
|
17327435 |
2007 |
|
rs2229109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in MDR1 between ESRD patients and healthy controls in the Chinese population to determine whether the alteration of the P-gp function is associated with ESRD.
|
17376299 |
2007 |
|
rs2431260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two intron 2 SNPs, rs2431260 (P = 0.015) and rs1709183 (P = 0.019), and a four-SNP haplotype containing these SNPs (P = 0.033) were associated with type 2 diabetes and/or ESRD.
|
17327435 |
2007 |
|
rs2648862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Markers rs13447075 (odds ratio [OR] 1.47 [95% CI 1.14-1.89] per copy of A allele; P = 0.003) and rs2648862 (2.66 [1.19-5.92] per copy of C allele; P = 0.008) were strongly associated with ESRD in analyses adjusting for age(2), age(3), duration of diabetes, and smoking status.
|
17881614 |
2007 |
|
rs2720709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We subsequently genotyped these 11 variants and an additional 87 SNPs identified through public databases in 319-kb flanking rs2720709 ( approximately 1 SNP/3.5 kb); 23 markers were associated with ESRD at P < 0.01.
|
17395743 |
2007 |
|
rs3759126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No correlation was found to exist between the AQP-2 gene polymorphism (rs3759126) and serum electrolyte levels in pre-ESRD patients (p = 0.38 for serum sodium level and p = 0.44 for serum potassium level).
|
17763164 |
2007 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of MTHFR 1298CC genotype was significantly higher in ESRD patients than in controls (21.4% vs. 2.9%); the frequency of the MTHFR C677T genotypes did not differ between groups (26.1% vs. 17.4%).
|
17899317 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It appears that Glu298Asp may be a predisposing factor in DM-derived and HT-derived ESRD.
|
18793530 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggested that the Glu298Asp polymorphism of NOS3 gene is associated with the onset age of ESRD.
|
18815450 |
2008 |
|
rs1801282
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
|
18467141 |
2008 |
|
rs1805192
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
|
18467141 |
2008 |