Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE Since the Glu298Asp variant in the eNOS gene alters caveolar localization of the corresponding enzyme, we tested the interaction between this variant and the rs4730751 polymorphism of the caveolin-1 (CAV-1) gene as related to arterial remodeling in end-stage renal disease (ESRD) patients. 21976276

2012

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE We tested the relationship between carotid intima-media thickness (IMT) and three endothelial NO synthase (eNOS) polymorphisms (G894T, T-786C, and 27-bp repeat in intron 4) in an ethnically and geographically homogeneous group of 147 patients with ESRD. 17586410

2007

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824

2006

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease. 16148605

2005

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males. 11823442

2002

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons). 11071967

2000

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE We detected significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD.Conclusion. 26881045

2016

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE We detected significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD.Conclusion. 26881045

2016

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE Future research should focus on the effect of Pro12Ala polymorphism on ESRD and gathering data of Africans. 22619290

2012

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE Future research should focus on the effect of Pro12Ala polymorphism on ESRD and gathering data of Africans. 22619290

2012

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy. 18467141

2008

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy. 18467141

2008

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE The aim of this study was to clarify whether the PPAR-gamma 161C/T and PPAR-gamma2 Pro12Ala single-nucleotide polymorphisms (SNPs) influence the inter-individual variance of inflammation and mortality in ESRD patients. 16115480

2006

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE The aim of this study was to clarify whether the PPAR-gamma 161C/T and PPAR-gamma2 Pro12Ala single-nucleotide polymorphisms (SNPs) influence the inter-individual variance of inflammation and mortality in ESRD patients. 16115480

2006

dbSNP: rs397507444
rs397507444
0.030 GeneticVariation BEFREE MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians. 17899317

2008

dbSNP: rs397507444
rs397507444
0.030 GeneticVariation BEFREE In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender. 16280279

2005

dbSNP: rs397507444
rs397507444
0.030 GeneticVariation BEFREE We genotyped 429 type 2 diabetic patients for the C677T and A1298C polymorphisms using standard PCR-based protocols, and divided them into three groups based on renal status: 159 patients with normoalbuminuria, 149 with microalbuminuria, and 121 with persistent proteinuria and chronic renal failure (CRF). 12897091

2003

dbSNP: rs121908529
rs121908529
0.020 GeneticVariation BEFREE Thus, in addition to G170R, other causative mutations are associated with later onset of end-stage renal disease. 24988064

2015

dbSNP: rs12437854
rs12437854
0.020 GeneticVariation BEFREE An association between ESRD and rs17709344, tagging the previously identified rs12437854 and located between the RGMA and MCTP2 genes, was replicated in independent case-control cohorts. rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno. 24871321

2015

dbSNP: rs12437854
rs12437854
0.020 GeneticVariation BEFREE After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)). 23028342

2013

dbSNP: rs3732378
rs3732378
0.020 GeneticVariation BEFREE We explored the role of CCR5-Δ32, CCR5-G59029A, CX3CR1 V249I and T280M gene polymorphisms as susceptibility for end stage renal disease (ESRD). 21132346

2011

dbSNP: rs3732379
rs3732379
0.020 GeneticVariation BEFREE There was significant difference in genotype frequencies of CCR5-G59029A (p = 0.005), and CX3CR1 V249I (p < 0.0001) between ESRD and controls. 21132346

2011

dbSNP: rs121908529
rs121908529
0.020 GeneticVariation BEFREE Among the 136 patients with DNA analysis, the most common mutation was p.Gly170Arg (allelic frequency 21.5%), with a median age at end-stage renal disease of 47 years for homozygotes, 35 years for heterozygotes, and 21 years for other mutations. 20016466

2010

dbSNP: rs3732378
rs3732378
0.020 GeneticVariation BEFREE The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis. 12846758

2004

dbSNP: rs3732379
rs3732379
0.020 GeneticVariation BEFREE The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis. 12846758

2004