|
rs61754966
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs12721593
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs61753720
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs899127658
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study was designed to prospectively evaluate the role of the TT677 methylenetetrahydrofolate reductase (MTHFR) genotype, the prothrombin G20210A mutation, the factor V G1691A mutation, deficiencies of protein C, protein S, antithrombin, and increased lipoprotein (a) concentrations in leukemic children treated according to the ALL-Berlin-Frankfurt-Muenster (BFM) 90/95 study protocols with respect to the onset of vascular events.
|
10029588 |
1999 |
|
rs34767364
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The R215W mutation was observed in one ALL but also in a population-based study and probably represents a rare sequence variant.
|
11325820 |
2001 |
|
rs569954362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs57725551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility.
|
12002748 |
2002 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The other HFE mutation H63D does not confer increased risk to childhood ALL.
|
12002748 |
2002 |
|
rs1275561861
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility.
|
12002748 |
2002 |
|
rs199474387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other HFE mutation H63D does not confer increased risk to childhood ALL.
|
12002748 |
2002 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL.
|
15059065 |
2004 |
|
rs1137101
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
rs140422742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Towards this aim we analyzed the CYP3A4-290A/G substitution and three NR3C1 polymorphisms (200G/A, 1220A/G and BclI RFLP) in 222 children with acute lymphoblastic leukemia (ALL) whose treatment protocols, among other components, contained corticosteroid drugs.
|
15462611 |
2004 |
|
rs368005287
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Towards this aim we analyzed the CYP3A4-290A/G substitution and three NR3C1 polymorphisms (200G/A, 1220A/G and BclI RFLP) in 222 children with acute lymphoblastic leukemia (ALL) whose treatment protocols, among other components, contained corticosteroid drugs.
|
15462611 |
2004 |
|
rs72481843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Towards this aim we analyzed the CYP3A4-290A/G substitution and three NR3C1 polymorphisms (200G/A, 1220A/G and BclI RFLP) in 222 children with acute lymphoblastic leukemia (ALL) whose treatment protocols, among other components, contained corticosteroid drugs.
|
15462611 |
2004 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T).
|
15717687 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.
|
16096524 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the MTHFR 677C>T and 1298A>C gene variants do not have a major influence on the susceptibility to pediatric ALL in the German population.
|
15921520 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data provide evidence that the MTHFR C677T polymorphism is a common genetic variant conferring a moderate relative risk and a high attributable risk for relapse in pediatric ALL patients.
|
15781665 |
2005 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the MTHFR 677C>T and 1298A>C gene variants do not have a major influence on the susceptibility to pediatric ALL in the German population.
|
15921520 |
2005 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.
|
16096524 |
2005 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In childhood acute lymphoblastic leukemia (ALL), there is an association of C282Y with a gender effect in two British populations.
|
15775751 |
2005 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |