|
rs1396171148
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1419129874
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1466642025
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1553553086
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1553554543
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs367956522
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs757075712
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1545224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b> Taken together, <i>FABP1</i> rs1545224 polymorphism might increase HCC risk in LC patients, indicating that <i>FABP1</i> rs1545224 polymorphism may be related to the process of developing HCC in Chinese patients with LC.
|
30519332 |
2018 |
|
rs1127354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs7270101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.
|
12865278 |
2003 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
H63D heterozygote and homozygote, occurring in less than 5% of the subjects, tended to be associated with the development of liver cirrhosis, irrespective of viral etiology.
|
15780041 |
2005 |
|
rs430397
|
|
|
0.020 |
GeneticVariation |
BEFREE |
rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers.
|
21779363 |
2011 |
|
rs12304647
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A Cox relative hazards model with adjustments for age, gender, HBeAg status, and cirrhosis revealed that rs12304647A>C retained its association with HCC in a codominant model (relative hazards [RH] = 1.14, P = 0.05) and in a recessive model (RH = 1.44, P = 0.03).
|
24248733 |
2014 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%).
|
10673304 |
2000 |
|
rs641738
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers.
|
26850495 |
2016 |
|
rs1346044973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel TERT variant, A243V, was identified in a 65-year-old male with advanced HCC and cirrhosis secondary to chronic hepatitis C virus (HCV) and alcohol ingestion, but direct assay measurements in vitro did not detect modulation of telomerase enzymatic activity or processivity.
|
28813500 |
2017 |
|
rs7254880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant allelic association was found between rs7254880 in ZNF699 and alcohol-related cirrhosis (n=292), using cases with no biopsy evidence of liver disease (n=314) as controls (P=0.013).
|
26368818 |
2015 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A small but significant number of Norwegian male C282Y homozygotes will contract liver cirrhosis if their hemochromatosis is not diagnosed and treated in time.
|
17710673 |
2007 |
|
rs28929474
|
|
|
0.050 |
GeneticVariation |
BEFREE |
According to retrospective studies, up to 25% of those with homozygous ZZ (Glu 342 to Lys) AATD suffer from liver cirrhosis and/or liver cancer in late adulthood.
|
21617532 |
2011 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According to ultrasound examinations, no association between PNPLA3 rs738409 genotype and fatty change of the liver or hepatic cirrhosis was found in Japanese patients infected with HCV.
|
24349054 |
2013 |
|
rs4074
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001).
|
24260493 |
2013 |
|
rs8021276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs8021276 polymorphism was also associated with down-regulation of AT3 mRNA expression and increasing AFB1-DNA adducts in liver tissues with cirrhosis.
|
29937988 |
2018 |