| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.790 | GeneticVariation | BEFREE | Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409 (p = .01, OR 1.9, 95% CI 1.1-3.1), a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis. | 28776448 | 2017 |
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0.790 | GeneticVariation | BEFREE | PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis. | 26493626 | 2016 |
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|
0.790 | GeneticVariation | BEFREE | Our meta-analysis shows that the rs738409 variant of PNPLA3 is clearly associated with alcoholic liver cirrhosis. | 25060292 | 2014 |
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|
0.790 | GeneticVariation | BEFREE | PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis. | 24102786 | 2014 |
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|
0.790 | GeneticVariation | BEFREE | This study provides key data that affirm the influence of the rs738409 (GG) genotype on the occurrence of HCC in patients with alcoholic cirrhosis. | 23069476 | 2013 |
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|
0.790 | GeneticVariation | BEFREE | The absence of an association of PNPLA3 p.I148M with alcoholic CP seems not to point to a common pathway in the development of alcoholic CP and alcoholic liver cirrhosis. | 22276112 | 2012 |
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|
0.790 | GeneticVariation | BEFREE | The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. | 22087248 | 2011 |
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|
0.790 | GeneticVariation | BEFREE | Genotype PNPLA3 rs738409(GG) is associated with alcoholic liver cirrhosis and elevated aminotransferase levels in alcoholic Caucasians. | 21254164 | 2011 |
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|
0.790 | GeneticVariation | BEFREE | We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)). | 19946271 | 2010 |