|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the association of the Arg72Pro polymorphism with skin cancer risk among Caucasians in a nested case-control study within the Nurses' Health Study (NHS) (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) and 874 controls).
|
16739124 |
2006 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the association of the Arg72Pro polymorphism with skin cancer risk among Caucasians in a nested case-control study within the Nurses' Health Study (NHS) (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) and 874 controls).
|
16739124 |
2006 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the association of the Arg72Pro polymorphism with skin cancer risk among Caucasians in a nested case-control study within the Nurses' Health Study (NHS) (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) and 874 controls).
|
16739124 |
2006 |
|
rs563378859
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We previously showed that mice carrying an activated Cdk4 mutation together with melanocyte-specific mutant Hras (Cdk4(R24C/R24C)/TPras) develop melanoma spontaneously, but penetrance is increased and age of onset reduced after neonatal ultraviolet radiation (UVR) exposure.
|
18386818 |
2008 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro.
|
19318491 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro.
|
19318491 |
2009 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prospectively enrolled melanoma patients (N = 227) were evaluated for MDM2 SNP309 and the related polymorphism, p53 Arg72Pro.
|
19318491 |
2009 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We detected the p.Gly23Asp missense mutation in one of the two tested melanoma patients of a family with three melanoma cases.
|
19712690 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs28934578
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since mutations in the p53 tumor suppressor gene contribute to drug resistance, we used genetically-matched human C8161 melanoma harbouring wt or DN-R175H mutant p53, to investigate the influence of p53 status on the potentiation of H(2)O(2) toxicity by: (a) intact sodium nitroprusside or nitroferricyanide (SNP), (b) its light-exhausted NO-depleted form (lex-SNP), (c) potassium ferricyanide, or (d) ferric ammonium sulphate.
|
20674559 |
2010 |
|
rs770374782
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A somatic, heterozygous IDH1 c.C394T (p.R132C) mutation was identified in one human melanoma metastasis to the lung.
|
20603105 |
2010 |
|
rs28934578
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since tumor cells face glucose and growth factor shortage when growing distant from sites of vascularization, we used genetically-matched human C8161 melanoma harbouring wt p53 or a tumor-associated (DN) mutant p53 (R175H), to investigate whether this mutation influences survival under metabolic stress.
|
21832879 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports.
|
22336942 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports.
|
22336942 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports.
|
22336942 |
2012 |
|
rs749817236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of potentially important mutation events occurred in TFG including the identification of a mini mutation "hotspot" at amino acid residue 380 (P380S and P380L) and the presence of multiple mutations in two melanomas.
|
22250051 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
rs121912654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |