|
rs137852789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation.
|
27863474 |
2016 |
|
rs121913343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two new mutations, the G542E exon 12 mutation variant of the FGFR2 gene and the R273C mutation variant of the p53 gene, are reported for the first time in BRAF mutant melanoma.
|
24858661 |
2014 |
|
rs1453167097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed for the first time that polymorphisms in p27 Val109Gly and in prohibitin 3'UTR C1703T genotypes modulate the risk to melanoma in a high UV index region.
|
23624368 |
2013 |
|
rs78378222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
|
23742673 |
2013 |
|
rs749817236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of potentially important mutation events occurred in TFG including the identification of a mini mutation "hotspot" at amino acid residue 380 (P380S and P380L) and the presence of multiple mutations in two melanomas.
|
22250051 |
2012 |
|
rs770374782
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Melanomas from 10 separate patients (4.9%) were positive for IDH1 R132C (nine) or R132S (one).
|
30003571 |
2018 |
|
rs121912654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation.
|
27863474 |
2016 |
|
rs121912654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
|
rs28934578
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since tumor cells face glucose and growth factor shortage when growing distant from sites of vascularization, we used genetically-matched human C8161 melanoma harbouring wt p53 or a tumor-associated (DN) mutant p53 (R175H), to investigate whether this mutation influences survival under metabolic stress.
|
21832879 |
2011 |
|
rs28934578
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since mutations in the p53 tumor suppressor gene contribute to drug resistance, we used genetically-matched human C8161 melanoma harbouring wt or DN-R175H mutant p53, to investigate the influence of p53 status on the potentiation of H(2)O(2) toxicity by: (a) intact sodium nitroprusside or nitroferricyanide (SNP), (b) its light-exhausted NO-depleted form (lex-SNP), (c) potassium ferricyanide, or (d) ferric ammonium sulphate.
|
20674559 |
2010 |
|
rs770374782
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A somatic, heterozygous IDH1 c.C394T (p.R132C) mutation was identified in one human melanoma metastasis to the lung.
|
20603105 |
2010 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We detected the p.Gly23Asp missense mutation in one of the two tested melanoma patients of a family with three melanoma cases.
|
19712690 |
2009 |
|
rs563378859
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To study the mutagenic mechanisms by which acute sunburn accelerates MM, we sequenced the exomes of spontaneous and neonatal UVB-induced Cdk4-R24C::Tyr-NRASQ61K mouse MMs.
|
26477315 |
2016 |
|
rs563378859
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Here, using a bigenic mouse model system combining mutant oncogenic NRAS(Q61K) (constitutively active RAS) or mutant activated CDK4(R24C/R24C) (prevents binding of CDK4 by kinase inhibitor p16(INK4A)) with an epidermis-specific knockout of the nuclear retinoid X receptor alpha (RXRα(ep-/-)) results in increased melanoma formation after chronic ultraviolet-B (UVB) irradiation compared with control mice with functional RXRα.
|
25189354 |
2015 |
|
rs563378859
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We previously showed that mice carrying an activated Cdk4 mutation together with melanocyte-specific mutant Hras (Cdk4(R24C/R24C)/TPras) develop melanoma spontaneously, but penetrance is increased and age of onset reduced after neonatal ultraviolet radiation (UVR) exposure.
|
18386818 |
2008 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs1042522 was also selected as a CM risk factor in multivariate models, suggesting an effect that is independent from and complementary to that of rs1805007.
|
31612033 |
2019 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Risk of cancer specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered.
|
28336930 |
2017 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Risk of cancer specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered.
|
28336930 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Risk of cancer specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered.
|
28336930 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that genotypes for the TP53 rs1042522 G>C polymorphism might not be associated with the risk of melanoma.
|
26148609 |
2016 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.
|
25774791 |
2015 |