Gene: MAP2K1 ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Melanoma genome sequencing reveals frequent PREX2 mutations. 22622578

2012
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs869025608
rs869025608
MAP2K1
T 0.700 GeneticVariation CLINVAR Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. 23444215

2013