Gene: MAP2K1 ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519731
rs1057519731
MAP2K1
C 0.720 CausalMutation CLINVAR We found that the acquired MEK1-C121S mutation in BRAF-V600E mutant melanoma conferred resistance to both vemurafenib and selumetinib but not E6201. 24448821

2014
dbSNP: rs397516792
rs397516792
MAP2K1
T 0.720 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519731
rs1057519731
MAP2K1
C 0.720 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
dbSNP: rs1057519731
rs1057519731
MAP2K1
C 0.720 CausalMutation CLINVAR Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. 21383288

2011
dbSNP: rs1057519731
rs1057519731
MAP2K1
C 0.720 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs397516792
rs397516792
MAP2K1
T 0.720 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs397516792
rs397516792
MAP2K1
T 0.720 CausalMutation CLINVAR COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. 21107320

2010
dbSNP: rs397516792
rs397516792
MAP2K1
T 0.720 CausalMutation CLINVAR One such mutation, MEK1(P124L), was identified in a resistant metastatic focus that emerged in a melanoma patient treated with AZD6244. 19915144

2009
dbSNP: rs727504317
rs727504317
MAP2K1
A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519729
rs1057519729
MAP2K1
C 0.700 GeneticVariation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
dbSNP: rs1057519733
rs1057519733
MAP2K1
A 0.700 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
dbSNP: rs1057519805
rs1057519805
MAP2K1
C 0.700 GeneticVariation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs397516790
rs397516790
MAP2K1
G 0.700 GeneticVariation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
dbSNP: rs869025608
rs869025608
MAP2K1
C 0.700 GeneticVariation CLINVAR Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. 23444215

2013
dbSNP: rs869025608
rs869025608
MAP2K1
T 0.700 GeneticVariation CLINVAR Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. 23444215

2013
dbSNP: rs1057519730
rs1057519730
MAP2K1
G 0.700 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Melanoma genome sequencing reveals frequent PREX2 mutations. 22622578

2012
dbSNP: rs1057519728
rs1057519728
MAP2K1
C 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519730
rs1057519730
MAP2K1
G 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519733
rs1057519733
MAP2K1
A 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519735
rs1057519735
MAP2K1 ; SNAPC5
C 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519729
rs1057519729
MAP2K1
C 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009