|
rs60662302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans.
|
28663758 |
2017 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly.
|
28712073 |
2017 |
|
rs763751076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly.
|
28712073 |
2017 |
|
rs771065515
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans.
|
28663758 |
2017 |
|
rs1572982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis for the rs1799945, rs1800730, rs1800562, rs2071303, rs1800708, and rs1572982 was performed on Russian patients with some metabolic disorders or stomach cancer and among long-lived people.
|
27317329 |
2016 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders.
|
26563278 |
2016 |
|
rs553668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders.
|
26563278 |
2016 |
|
rs13702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown.
|
25811490 |
2015 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases.
|
26578807 |
2015 |
|
rs301
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown.
|
25811490 |
2015 |
|
rs328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown.
|
25811490 |
2015 |
|
rs5767700
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight single nucleotide polymorphisms in the PPARα gene were chosen from either the HapMap CHB database or previous reports.The distribution of metabolic disorders differed significantly between the wild-type and variant genotypes of both the rs5767743 and rs5767700 loci (P < 0.05 for all).
|
26334901 |
2015 |
|
rs5767743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight single nucleotide polymorphisms in the PPARα gene were chosen from either the HapMap CHB database or previous reports.The distribution of metabolic disorders differed significantly between the wild-type and variant genotypes of both the rs5767743 and rs5767700 loci (P < 0.05 for all).
|
26334901 |
2015 |
|
rs11066280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs11635252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the CRTC3 polymorphism rs3862434 was associated with the plasma level of total cholesterol, and rs11635252 was associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population, which might strengthen our understanding of the complex heredity of metabolic disorders.
|
24264430 |
2014 |
|
rs1431648262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This perturbation in the desensitization-resensitization cycle of the GIPR variant, revealed in studies of cultured adipocytes, may contribute to the link of the E354Q variant to metabolic disease.
|
25047836 |
2014 |
|
rs17249754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease.
|
25077953 |
2014 |
|
rs267606841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, the prediction of high damaging behavior, evolutionary conservation and structural destabilization for C574G were proposed as major contributing factors to regulate metabolic disorder underlying tumor calcinosis and hyperostosis-hyperphosphatemia syndrome.
|
24038392 |
2014 |
|
rs3862434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the CRTC3 polymorphism rs3862434 was associated with the plasma level of total cholesterol, and rs11635252 was associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population, which might strengthen our understanding of the complex heredity of metabolic disorders.
|
24264430 |
2014 |
|
rs4938723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that rs4938723 in the promoter region of pri-miR-34b/c and the SNP in TP53 codon 72 were related to decreased risk of CRC in the population studied and those metabolic diseases and genetic variants influence each other with regard to CRC susceptibility.
|
24337371 |
2014 |
|
rs7076156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of polymorphisms TaqI and FokI of VDR gene and Ala62Thr of ZNF365 gene with the metabolic disorders (MD) in children with urolithiasis (UL).We included 109 children with UL.
|
25060549 |
2014 |
|
rs1799904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings that this novel R80Q (rs1799904) variant both exhibits adverse effects on PC1/3 activity and is prevalent in the population suggests that further biochemical and genetic analysis to assess its contribution to the risk of metabolic disease within the general population is warranted.
|
23383060 |
2013 |
|
rs324420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of FAAH (fatty acid amide hydrolase) was associated with obesity and metabolic disorders.
|
22609216 |
2013 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significant association between D299G polymorphism and metabolic disorders (T2DM and Met-S) risk (OR = 0.566, 95 % CI: 0.347-0.925, p = 0.023) particularly in Caucasians.
|
23275193 |
2013 |