|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Genotyping for ABCB1 1236C>T, 2677G>A/T, and 3435C>T polymorphisms was performed, and the effects of ABCB1 polymorphisms on AUC<sub>0-24</sub> for lenalidomide were compared in 36 patients with MM who were administered lenalidomide according to the drug label based on CCr.
|
31089832 |
2019 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The overall results showed no significant association between the MDR1 (rs1045642 C > T) polymorphism and the risk of MM in genetic models (dominant model: OR = 1.04, 95% CI = 0.78-1.38; recessive model: OR = 0.74, 95% CI = 0.52-1.06; allelic model: OR = 0.90, 95% CI = 0.73-1.11; TT vs. CC: OR = 0.80, 95% CI = 0.51-1.25; and CT vs. CC: OR = 1.12, 95% CI = 0.77-1.62).
|
29495954 |
2018 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MDR1 alleles at locus C1236T with T had significant lower calcium level in MM patients compared with C. The genotype CT had a significantly prolonged progress free survival (PFS) compared genotype CC at locus C1236T (median time: 48 months vs. 28 months, respectively; p=0.0062; HR=0.21; 95%CI0.061-0.715) while patients carrying T allele (CT and TT) at locus C3435T had a longer PFS than patients without T allele (CC) (median time: 60 months vs. 29 months, respectively; p=0.038; HR=0.508; 95%CI 0.264-0.978).
|
28888211 |
2017 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Additionally, there are three SNPs (rs1045642, rs2032582 and rs1128503) within the most widely studied of these genes, ABCB1, which have been suggested to have a potential impact on OS in PCM and which may form a haplotype in ABCB1. rs1045642 in ABCB1 appears to be the only SNP affecting OS within the PCM patients studied, with minimal linkage disequilibrium demonstrated between it and rs2032582 and rs1128503.
|
21705081 |
2011 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Findings within the PCM cohort suggest that rs1045642 genotype influences OS (p</span> = 2 x 10(-2)).
|
19373654 |
2009 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Here, we investigated whether common MDR1 single nucleotide polymorphisms (1236C>T, 2677G>A/T and 3435C>T) affect predisposition to multiple myeloma.
|
18639335 |
2009 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MDR1 alleles at locus C1236T with T had significant lower calcium level in MM patients compared with C. The genotype CT had a significantly prolonged progress free survival (PFS) compared genotype CC at locus C1236T (median time: 48 months vs. 28 months, respectively; p=0.0062; HR=0.21; 95%CI0.061-0.715) while patients carrying T allele (CT and TT) at locus C3435T had a longer PFS than patients without T allele (CC) (median time: 60 months vs. 29 months, respectively; p=0.038; HR=0.508; 95%CI 0.264-0.978).
|
28888211 |
2017 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, there are three SNPs (rs1045642, rs2032582 and rs1128503) within the most widely studied of these genes, ABCB1, which have been suggested to have a potential impact on OS in PCM and which may form a haplotype in ABCB1. rs1045642 in ABCB1 appears to be the only SNP affecting OS within the PCM patients studied, with minimal linkage disequilibrium demonstrated between it and rs2032582 and rs1128503.
|
21705081 |
2011 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, there are three SNPs (rs1045642, rs2032582 and rs1128503) within the most widely studied of these genes, ABCB1, which have been suggested to have a potential impact on OS in PCM and which may form a haplotype in ABCB1. rs1045642 in ABCB1 appears to be the only SNP affecting OS within the PCM patients studied, with minimal linkage disequilibrium demonstrated between it and rs2032582 and rs1128503.
|
21705081 |
2011 |
|
rs1289543302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we investigated whether common MDR1 single nucleotide polymorphisms (1236C>T, 2677G>A/T and 3435C>T) affect predisposition to multiple myeloma.
|
18639335 |
2009 |