| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.040 | GeneticVariation | BEFREE | A promoter SNP -168A→G (rs3087456) has previously been shown to be associated with susceptibility to several immune mediated disorders, including rheumatoid arthritis (RA), multiple sclerosis (MS) and myocardial infarction (MI). | 20942939 | 2010 |
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0.040 | GeneticVariation | BEFREE | In addition, the -168A/G CIITA promoter variant (rs3087456) has been reported to be associated with MS. | 20211854 | 2010 |
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0.040 | GeneticVariation | BEFREE | A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population. | 17012290 | 2007 |
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0.040 | GeneticVariation | BEFREE | We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis. | 16426246 | 2006 |
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0.030 | GeneticVariation | BEFREE | We also confirm interaction between rs4774 and HLA-DRB1*15:01 such that individuals carrying the risk allele for rs4774 and HLA-DRB1*15:01 have a higher than expected risk for MS. | 24430172 | 2014 |
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0.030 | GeneticVariation | BEFREE | Recently the rs4774 CIITA missense variant (+1632G/C) was reported to be associated with susceptibility to multiple sclerosis. | 21614020 | 2011 |
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0.030 | GeneticVariation | BEFREE | Rs4774 (missense +1614G/C; G500A) was associated with MS (P = 4.9 x 10(-3)), particularly in DRB1*1501 +individuals (P = 1 x 10(-4)). | 20211854 | 2010 |
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0.030 | GeneticVariation | BEFREE | Rs4774 (missense +1614G/C; G500A) was associated with MS (P = 4.9 x 10(-3)), particularly in DRB1*1501 +individuals (P = 1 x 10(-4)). | 20211854 | 2010 |