rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction.
|
18459066 |
2009 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest).
|
18505420 |
2008 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association between the rs10757278 SNP and myocardial infarction and binary (presence/absence) angiographic classifications of CAD.
|
20729229 |
2010 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America.
|
18048766 |
2008 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found even more significant association between rs</span>10757278 polymorphism and MI in pooled population, p = 3.55 × 10-53, after excluding the study from the Pakistan population.
|
26006241 |
2015 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We related SNPs rs2383207 and rs10757278 to stroke and to myocardial infarction and coronary revascularizations (coronary events) using crude and multivariate adjusted Cox proportional hazards models.
|
19293724 |
2009 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified 2 single-nucleotide polymorphisms (SNPs) on chromosome arm 9p21, rs10757278, and rs2383207 that confer susceptibility to myocardial infarction.
|
23454037 |
2013 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of the study was to find whether patients carrying polymorphic allele of the rs10757278 polymorphism from 9p21 locus have changed risk of arrhythmia (atrial fibrillation, AF; sustained ventricular tachycardia or ventricular fibrillation, sVT/VF) during acute phase of myocardial infarction.
|
26615606 |
2016 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI).
|
18925945 |
2008 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms.
|
20031606 |
2009 |
rs10757278
|
|
|
0.900 |
GeneticVariation |
BEFREE |
While we confirmed the association of rs10757278 with CDKN2B expression in MI patients, we failed to find an association between the investigated variants and MI or disease burden.
|
31386834 |
2019 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
|
22216278 |
2011 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027).
|
23856978 |
2013 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk.
|
26961926 |
2016 |
rs4977574
|
|
|
0.880 |
GeneticVariation |
BEFREE |
After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time.
|
24475106 |
2014 |
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Genome-wide association studies have described an association between MIA3 rs17465637 A/C polymorphisms and coronary artery disease and myocardial infarction.
|
22577832 |
2012 |
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
SNPs were genotyped by TaqMan assays and follow-up multivariate logistic regression analysis with incorporation of significant covariates showed significant association with MI for MIA3 SNP rs17465637 (P-adj= 0.0034) and SORT1 SNP rs599839 (P-adj= 0.009).
|
21463265 |
2011 |
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Showing association between rs17465637 and MI, this work was consistent with results from the original detection study and most prior replication studies addressing this issue.
|
21264445 |
2011 |
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Although the underlying mechanisms are not clearly understood, the previously reported association between the 2 SNPs (rs1333049 and rs17465637) and MI was reproduced in this Japanese sample.
|
18654002 |
2008 |
rs12526453
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |