Gene: RAD51C ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1567799818
rs1567799818
RAD51C
T 0.700 CausalMutation CLINVAR

dbSNP: rs1567799943
rs1567799943
RAD51C
C 0.700 GeneticVariation CLINVAR

dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Genetic testing for RAD51C mutations: in the clinic and community. 25470109

2015
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families. 25086635

2014
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Germline RAD51C mutations in ovarian cancer susceptibility. 22725699

2013
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716

2012
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. 24240112

2014
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Germline mutations in RAD51C in Jewish high cancer risk families. 23117857

2012
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. 28588062

2017
dbSNP: rs267606997
rs267606997
RAD51C
A 0.700 GeneticVariation CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016
dbSNP: rs267606997
rs267606997
RAD51C
A 0.700 GeneticVariation CLINVAR Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations. 25154786

2015
dbSNP: rs267606997
rs267606997
RAD51C
A 0.700 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183

2012
dbSNP: rs267606997
rs267606997
RAD51C
A 0.700 GeneticVariation CLINVAR Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963

2010
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. 26354865

2015
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy. 26678223

2016
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Genetic testing for RAD51C mutations: in the clinic and community. 25470109

2015
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183

2012
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787

2014
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964

2010
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. 25292178

2015
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. 23438602

2013
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. 24993905

2014
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. 28829762

2017
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. 22451500

2012