Gene: RAD51C ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1555605074
rs1555605074
RAD51C ; LOC105371843
T 0.700 GeneticVariation CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075

2017
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. 28588062

2017
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. 28829762

2017
dbSNP: rs387907159
rs387907159
RAD51C
T 0.700 CausalMutation CLINVAR Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. 28281021

2017
dbSNP: rs587781410
rs587781410
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer. 28905878

2017
dbSNP: rs587781410
rs587781410
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075

2017
dbSNP: rs759292615
rs759292615
RAD51C ; LOC105371843
A 0.700 GeneticVariation CLINVAR Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction. 29054568

2017
dbSNP: rs767796996
rs767796996
RAD51C
C 0.700 GeneticVariation CLINVAR The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer. 27622768

2017
dbSNP: rs770637624
rs770637624
RAD51C
T 0.700 CausalMutation CLINVAR Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer. 28024868

2017
dbSNP: rs200293302
rs200293302
RAD51C
T 0.700 CausalMutation CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016
dbSNP: rs267606997
rs267606997
RAD51C
A 0.700 GeneticVariation CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016
dbSNP: rs267606999
rs267606999
RAD51C
C 0.700 GeneticVariation CLINVAR Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy. 26678223

2016
dbSNP: rs587780259
rs587780259
RAD51C
G 0.700 CausalMutation CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312

2016
dbSNP: rs587781287
rs587781287
RAD51C ; LOC105371843
T 0.700 CausalMutation CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728

2016
dbSNP: rs587781410
rs587781410
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing. 27621404

2016
dbSNP: rs587781995
rs587781995
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. 26822949

2016
dbSNP: rs730881939
rs730881939
RAD51C
TA 0.700 CausalMutation CLINVAR Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair. 26848151

2016
dbSNP: rs730881939
rs730881939
RAD51C
TA 0.700 CausalMutation CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312

2016
dbSNP: rs730881942
rs730881942
RAD51C ; TEX14
C 0.700 CausalMutation CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312

2016
dbSNP: rs730881942
rs730881942
RAD51C ; TEX14
C 0.700 CausalMutation CLINVAR Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. 27433846

2016
dbSNP: rs746993675
rs746993675
RAD51C
G 0.700 CausalMutation CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016
dbSNP: rs770637624
rs770637624
RAD51C
T 0.700 CausalMutation CLINVAR Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. 27433846

2016
dbSNP: rs779582317
rs779582317
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728

2016
dbSNP: rs779582317
rs779582317
RAD51C ; LOC105371843
C 0.700 GeneticVariation CLINVAR Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer. 26824983

2016
dbSNP: rs1413872299
rs1413872299
RAD51C
C 0.700 GeneticVariation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251

2015