|
rs880395
|
|
|
0.020 |
GeneticVariation |
BEFREE |
4-SNP haplotype and diplotype analyses (rs880395-rs16969968-rs1948 -rs4887074) yield nicotine dependence risk values that further differentiate those obtained with the 3-SNP model.
|
30453884 |
2018 |
|
rs1948
|
|
|
0.020 |
GeneticVariation |
BEFREE |
4-SNP haplotype and diplotype analyses (rs880395-rs16969968-rs1948 -rs4887074) yield nicotine dependence risk values that further differentiate those obtained with the 3-SNP model.
|
30453884 |
2018 |
|
rs2472553
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A cytosine to thymidine (C → T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR) α2 subunit produces a threonine-to-isoleucine substitution (T22I) often associated with nicotine dependence (ND).
|
24467848 |
2014 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A rare variant of chromosomal region 15q25.1, marked by rs16969968 (substitution 1354G>A in CHRNA5), was found to be associated with increased lung cancer and nicotine-dependence risk.
|
21955800 |
2012 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence.
|
19429911 |
2009 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.
|
29573323 |
2018 |
|
rs1799971
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.
|
22676196 |
2012 |
|
rs1360780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 296 female smokers (assessed by the Fagerström Test for Nicotine Dependence; FTND) were genotyped for the SNP rs1360780.
|
27062383 |
2016 |
|
rs1051730
|
|
T |
0.790 |
GeneticVariation |
GWASDB |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
|
18385739 |
2008 |
|
rs958331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After analyzing the SAGE data, we identify three genetic variants (rs7672861, rs958331, rs879330) that are significantly associated with the comorbidity of alcohol and nicotine addiction at the chromosome-wide level.
|
30666272 |
2018 |
|
rs879330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After analyzing the SAGE data, we identify three genetic variants (rs7672861, rs958331, rs879330) that are significantly associated with the comorbidity of alcohol and nicotine addiction at the chromosome-wide level.
|
30666272 |
2018 |
|
rs1044394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, the association between rs1044394 and ND in the combined sample remained significant (P = 0.033).
|
21445957 |
2011 |
|
rs557748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After permutation and FDR adjustment, none of the associations remained statistically significant, although the p-values for the association between rs557748 in OPRM1 and the ND/craving and self-medication phenotypes were both 0.076.
|
25545355 |
2014 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected in the context of the German multi-centre study ׳Genetics of Nicotine Dependence and Neurobiological Phenotypes׳.
|
26612384 |
2016 |
|
rs11636753
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, rs11636753 in CHRNB4 showed suggestive association with regular drinking (p = .0029) and the comorbidity of depression and ND (p = .0034).
|
22241830 |
2012 |
|
rs4424567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we found two SNPs significantly associated with ND; one in the FERM domain containing 4A (rs4424567, p value(meta) = 2.30 × 10(-6)) and the other at 7q31.1 (rs848353, p value(meta) = 9.16 × 10(-8)).
|
22006218 |
2012 |
|
rs848353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we found two SNPs significantly associated with ND; one in the FERM domain containing 4A (rs4424567, p value(meta) = 2.30 × 10(-6)) and the other at 7q31.1 (rs848353, p value(meta) = 9.16 × 10(-8)).
|
22006218 |
2012 |
|
rs2242449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no SNP in DLG4 was significantly associated with ND, we found a G-G haplotype with a frequency of 14.2% formed by SNPs rs2242449 and rs507506 within the gene that showed significant inverse associations with all three ND measures [P = 0.003, 0.015 and 0.024, for SQ (defined as the number of cigarettes smoked per day), HSI and FTND, respectively].
|
17164261 |
2007 |
|
rs507506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no SNP in DLG4 was significantly associated with ND, we found a G-G haplotype with a frequency of 14.2% formed by SNPs rs2242449 and rs507506 within the gene that showed significant inverse associations with all three ND measures [P = 0.003, 0.015 and 0.024, for SQ (defined as the number of cigarettes smoked per day), HSI and FTND, respectively].
|
17164261 |
2007 |
|
rs12718541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although sequence analysis suggests that rs12718541 may be an intronic splicing enhancer, further studies are needed to determine whether a direct link exists between an alternatively spliced form of DDC and predisposition to ND.
|
16740595 |
2006 |
|
rs2653349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the p value did not reach a conventional genome-wide level of significance in our two-stage GWAS, we obtained significant results in the subsequent analyses that suggest that the rs2653349 SNP (Val308Ile) could be a genetic factor that is related to nicotine dependence and possibly pain, schizotypal personality traits, and goiter in the Japanese population.
|
26289589 |
2015 |
|
rs4532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although we found significant associations of SNPs rs265973, rs686, and rs4532 in the AA sample; of rs4532 in the EA sample; and of rs265975, rs686, and rs4532 in the pooled sample with various ND measures, only the association of rs686 in the AA sample and of rs686 and rs4532 in the pooled sample remained significant after correction for multiple testing.
|
18092181 |
2008 |
|
rs1800955
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among Mexican mestizos, the C allele of rs1800955 in the DRD4 gene and the A allele of rs6311 in the HTR2A gene are associated with cigarette smoking, whereas the T allele of rs6313 in HTR2A is associated with cigarette smoking and the degree of nicotine addiction.
|
28103253 |
2017 |
|
rs6311
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among Mexican mestizos, the C allele of rs1800955 in the DRD4 gene and the A allele of rs6311 in the HTR2A gene are associated with cigarette smoking, whereas the T allele of rs6313 in HTR2A is associated with cigarette smoking and the degree of nicotine addiction.
|
28103253 |
2017 |
|
rs6313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among Mexican mestizos, the C allele of rs1800955 in the DRD4 gene and the A allele of rs6311 in the HTR2A gene are associated with cigarette smoking, whereas the T allele of rs6313 in HTR2A is associated with cigarette smoking and the degree of nicotine addiction.
|
28103253 |
2017 |