|
rs10082479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype-based association analysis revealed that haplotypes G-G-A-C, formed by rs1880676-rs3810950-rs10082479-rs8178990 (P = 0.005-0.0178), and G-G-T-C-G-C, formed by rs1880676-rs3810950-rs10082479-rs8178990-rs3793790-rs12266458 (P = 0.00247-0.00468), displayed significant association with all three ND measures in the AA sample, as did haplotype T-C-G-A-T, formed by rs12266458-rs11101191-rs8178991-rs4838544-rs4838547 (P = 0.00741-0.0103), in the EA sample.
|
20383528 |
2010 |
|
rs1042173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering biological functions of the three genes, we examined interactive effects of variants in the three genes, which revealed significant interactions among rs1062613 and rs10160548 in HTR3A, rs1176744 in HTR3B, and 5-HTTLPR and rs1042173 in SLC6A4 in affecting ND in the three samples.
|
23290502 |
2013 |
|
rs1044394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, the association between rs1044394 and ND in the combined sample remained significant (P = 0.033).
|
21445957 |
2011 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected in the context of the German multi-centre study ׳Genetics of Nicotine Dependence and Neurobiological Phenotypes׳.
|
26612384 |
2016 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Univariate (single-marker) family-based association tests (FBATs) demonstrated that variant alleles at two SNPs, rs1044396 and rs1044397, in exon 5 of the CHRNA4 gene were significantly associated with a protective effect against nicotine addiction as either a dichotomized trait or a quantitative phenotype (i.e., age-adjusted FTND and RTQ scores), which was consistent with the results of the global haplotype FBAT.
|
15154117 |
2004 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated a synonymous single nucleotide polymorphisms (SNP): rs1044396, which has recently been associated with nicotine-dependence, plus two adjacent synonymous SNPs rs1044394 and rs1044393 in exon 5 of n = 47 unrelated healthy Caucasian subjects (age: 22.7 +/- 1.7 years; sex: n = 23 males; regular smokers: n = 19).
|
17613539 |
2007 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.
|
21740768 |
2011 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, we demonstrated a possible gene-gene interaction of CHRNA4 and CHRNB2 on ND in a dose-dependent manner: those smokers with CHRNA4 rs1044397 GG or GA genotypes along with CHRNB2 rs4845652 CC genotype are likely to demonstrate higher ND scores.
|
23037950 |
2013 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Univariate (single-marker) family-based association tests (FBATs) demonstrated that variant alleles at two SNPs, rs1044396 and rs1044397, in exon 5 of the CHRNA4 gene were significantly associated with a protective effect against nicotine addiction as either a dichotomized trait or a quantitative phenotype (i.e., age-adjusted FTND and RTQ scores), which was consistent with the results of the global haplotype FBAT.
|
15154117 |
2004 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.
|
21740768 |
2011 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, rs755203 and rs1044397 in CHRNA4 might play a role in the pathophysiology of nicotine dependence in healthy controls in the Japanese population.
|
23553665 |
2013 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Using a cutoff point for the FTND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing).
|
20712524 |
2010 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
These data confirm the effect of rs1051730 on nicotine dependence but failed to find any relationship with difficulty, willingness, and motivation to quit.
|
21511889 |
2011 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes.
|
21232152 |
2011 |
|
rs1051730
|
|
T |
0.790 |
GeneticVariation |
GWASDB |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
|
18385739 |
2008 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group.
|
21747048 |
2011 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence.
|
23604333 |
2013 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence.
|
19429911 |
2009 |
|
rs1079597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among smokers with DRD2 rs1079597 GG//MAOA rs309850 3-repeat, the OR of heavier smoking was 2.67 times higher (95% confidence interval [CI]: [1.08, 6.59], p = .031) and the score on the Fagerstrom test for nicotine dependence was higher (4.26 vs. 2.83) than in those with DRD2 rs1079597 AA//MAOA rs309850 3-repeat.
|
26015071 |
2015 |
|
rs10798059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia.
|
31492433 |
2019 |
|
rs10865246
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in NRXN1 and two in CHRNA5 were associated with cigarette consumption, while rs10865246/C (NRXN1) was associated with high nicotine addiction.
|
27355804 |
2016 |
|
rs1122530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed that even after Bonferroni correction, the haplotype T-T-A of rs1659400-rs1187272-rs1122530 had a highly significant positive association, with adjusted ND measures in the EA sample (max Z = 3.78; p = .0001, frequency 59.9%).
|
16713586 |
2007 |