|
rs8103849
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the genotype frequencies of SNP rs2656927 (P = 0.014) and rs8103849 (P < 0.001) significantly differed between men with oligozoospermia in case group 1 and normozoospermic men.
|
31802345 |
2019 |
|
rs10966811
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia.
|
28975488 |
2018 |
|
rs12348
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we assessed the relationship between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility traits, we found that rs12348 in TUSC1 was significantly associated with azoospermia and oligozoospermia, but rs2772579 in IZUMO3 was not associated with male infertility.
|
28975488 |
2018 |
|
rs12376894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia.
|
28975488 |
2018 |
|
rs202007462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both groups showed nearly identical distributions of the SOAT-L204F polymorphism (∼10% heterozygous and ∼5% homozygous), indicating that this polymorphism seems not be causative for hypospermatogenesis.
|
28951225 |
2018 |
|
rs61734716
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both groups showed nearly identical distributions of the SOAT-L204F polymorphism (∼10% heterozygous and ∼5% homozygous), indicating that this polymorphism seems not be causative for hypospermatogenesis.
|
28951225 |
2018 |
|
rs144944885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a result, the 50776482 delC intronic variant (rs144944885) was identified in five patients with oligoasthenoteratozoospermia defect and one patient with ISTS defect in heterozygote form.
|
28138870 |
2017 |
|
rs886039769
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The father of the patients showed oligozoospermia with the p.R92W mutation, suggesting that in 46,XY individuals, the mutation would cause various gonadal phenotypes.
|
29393271 |
2017 |
|
rs147894843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants identified in SEMGs possibly contributing to hyperviscosity and asthenozoospermia consisted of three replacements predicted to modify targets of proteolysis (P = 0.0442 for SEMG1 p.Gly400Asp) and a copy number variation associated with a reduced risk of oligozoospermia (P = 0.0293).
|
27827323 |
2016 |
|
rs16895863
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs2274911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous subjects for the risk allele A of rs2274911 had a 4.60-fold increased risk of oligozoospermia and 3.52-fold increased risk of cryptorchidism.
|
26735260 |
2016 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the heterozygosity of rs28362491 in the NF-
|
27041523 |
2016 |
|
rs373341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs3749897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs696
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized a possible relationship between the NF-
|
27041523 |
2016 |
|
rs11204546
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although this study was somewhat limited by overall sample size, the OR2W3 gene polymorphism rs11204546 was significantly associated with oligospermia in Japanese men, suggesting that OR2W3 might be involved in genetic susceptibility to Japanese male infertility as well as in European males.
|
25847845 |
2015 |
|
rs1801394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.
|
25578539 |
2015 |
|
rs1805087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.
|
25578539 |
2015 |
|
rs55763075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distributions of the rs55763075 single nucleotide polymorphism were investigated by polymerase chain reaction and direct sequencing in a Chinese cohort that included 464 infertile men with idiopathic azoospermia or oligospermia and 458 controls with normal fertility.
|
26505368 |
2015 |
|
rs724078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no associations between rs724078 and azoospermia or oligozoospermia.
|
25908656 |
2015 |
|
rs7867029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs rs7867029 and rs7174015 are associated with oligozoospermia [rs7867029: odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.07-2.68, P = 0.024 (log-additive); rs7174015: OR = 6.52, 95% CI = 1.57-27.10, P = 0.0099 (dominant)] and rs12870438 is associated with azoospermia (OR = 10.90, 95% CI = 2.67-44.60, P = 0.00087 (recessive)] and oligozoospermia [OR = 8.54, 95% CI = 1.52-47.90, P = 0.015 (recessive)].
|
25908656 |
2015 |
|
rs1136410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that genotype CC of SNP rs1136410 may increase the risk of oligosoermia and genotype TT of rs1136410 may have some protective effect from oligospermia, suggesting that the polymorphism of SNP rs1136410 in PARP1 gene may modify the susceptibility to male infertility with oligospermia.
|
25106941 |
2014 |
|
rs16999593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of rs16999593 allele A (83.6% versus 77.6%, P=0.033) and genotype AA (69.2% versus 59.0%, P=0.037) and SNP rs2228611 genotype AA (18.4% versus 9.9%, P=0.016) in patients with oligospermia were significantly higher than those in control group.
|
24631383 |
2014 |
|
rs2228611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of rs16999593 allele A (83.6% versus 77.6%, P=0.033) and genotype AA (69.2% versus 59.0%, P=0.037) and SNP rs2228611 genotype AA (18.4% versus 9.9%, P=0.016) in patients with oligospermia were significantly higher than those in control group.
|
24631383 |
2014 |
|
rs10269148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic variant rs10269148 of STRA8 gene showed higher risk of spermatogenic impairment in the groups of abnormospermia (including azoospermia subgroup and oligozoospermia subgroup) and azoospermia than the controls with odds ratios and 95% confidence intervals of 2.52 (1.29-4.94) and 2.92 (1.41-6.06), respectively (P = 0.006, 0.002 respective).
|
23320086 |
2013 |