Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE In this meta-analysis, the results indicate the OPRM1 A118G polymorphism was associated with the opioid requirement and the adverse effects in pain treatment especially in postoperative pain. 31337162

2019

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE OPRM1-A118G polymorphism (A > G, rs1799971) is associated with interindividual variability in both response to postoperative pain and opioid treatment. 30323865

2018

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption. 27903758

2017

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and so optimize postoperative pain control. 23909491

2013

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. 21383334

2012

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE This study shows that the OPRM1 118A>G polymorphism affects postoperative pain response in heterozygous patients: they have a different postoperative pain response than patients with wild-type genes, which may affect the efficacy of the analgesic therapy. 22230405

2012

dbSNP: rs1799971
rs1799971
0.070 GeneticVariation BEFREE These results suggest that the A118G SNP may moderate but not mediate the effects of anger-out on postoperative pain responses. 16400534

2006

dbSNP: rs1045642
rs1045642
0.030 GeneticVariation BEFREE Single-nucleotide polymorphism C3435T in the ABCB1 gene is associated with opioid consumption in postoperative pain. 24034787

2013

dbSNP: rs1045642
rs1045642
0.030 GeneticVariation BEFREE The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. 21383334

2012

dbSNP: rs1045642
rs1045642
0.030 GeneticVariation BEFREE Women with the T allele of C3435T polymorphism showed a trend towards a higher risk of developing persistent postoperative pain. 20627697

2010

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption. 27903758

2017

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE The associations of four COMT SNPs (rs6269, rs4633, rs4818 and rs4680) with postoperative pain were analyzed and outcome measures included maximum pain scores, need for postoperative opioid interventions and postoperative morphine requirements. 24533707

2014

dbSNP: rs1718125
rs1718125
0.010 GeneticVariation BEFREE Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer. 30762755

2019

dbSNP: rs3745367
rs3745367
0.010 GeneticVariation BEFREE Only 1 variant of the resistin gene (rs3745367) demonstrated a significant association with postoperative pain (P < .002). 29649030

2019

dbSNP: rs3732765
rs3732765
0.010 GeneticVariation BEFREE In the second association study of postoperative pain, subjects carrying the minor T allele of the rs3732765 SNP demonstrated more intense 24-hour postoperative pain compared with subjects not carrying this allele although total 24-hour postoperative opioid consumptions based on weight were comparable. 28472364

2018

dbSNP: rs13080116
rs13080116
0.010 GeneticVariation BEFREE The SNP rs33985936 and rs13080116 may serve as novel predictors for postoperative pain</span>. 28953656

2017

dbSNP: rs33985936
rs33985936
0.010 GeneticVariation BEFREE The SNP rs33985936 and rs13080116 may serve as novel predictors for postoperative pain. 28953656

2017

dbSNP: rs373611092
rs373611092
0.010 GeneticVariation BEFREE Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption. 27903758

2017

dbSNP: rs3845446
rs3845446
0.010 GeneticVariation BEFREE Opposite Associations Between the rs3845446 Single-Nucleotide Polymorphism of the CACNA1E Gene and Postoperative Pain-Related Phenotypes in Gastrointestinal Surgery Versus Previously Reported Orthognathic Surgery. 27480382

2016

dbSNP: rs4286289
rs4286289
0.010 GeneticVariation BEFREE Notably, our results provide the first indication that SCN9A SNP rs4286289 can be used as a predictor for hypersensitivity to postoperative pain. 26752484

2016

dbSNP: rs4818
rs4818
0.010 GeneticVariation BEFREE The associations of four COMT SNPs (rs6269, rs4633, rs4818 and rs4680) with postoperative pain were analyzed and outcome measures included maximum pain scores, need for postoperative opioid interventions and postoperative morphine requirements. 24533707

2014

dbSNP: rs795484
rs795484
0.010 GeneticVariation BEFREE Postoperative pain scores ≥ 7/10 were associated with rs795484 (G>A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01). 24909733

2014

dbSNP: rs2032582
rs2032582
0.010 GeneticVariation BEFREE The aim of the study was to search for an association between the single-nucleotide polymorphisms A118G in OPRM1 and C3435T and G2677T/A in ABCB1 and the analgesic effect of intravenous oxycodone in postoperative pain. 21383334

2012