Gene: SLC41A1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE SNPs rs11240569, rs708727, and rs823156 in <i>SLC41A1</i> Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson's Disease and Healthy Controls: Statistics and Machine-Learning Evidence. 31546642

2019
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE Through meta-analysis, we confirmed that minor variants of rs823128A>G, rs1572931C>T, and rs823156A>G played protective roles in PD. 28749816

2017
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE Through bioinformatic analysis, we predicted that rs823128, rs1572931, and rs823156 as noncoding variants of NUCKS1, RAB29, and SLC41A1, respectively, might affect PD risk by altering the transcription factor-binding capability of the genes. 28749816

2017
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE The PARK16 SNPs rs823128, rs947211, and rs823156 and the CAAAC, TGAGA, and CAGAC haplotypes may be significantly associated with sporadic PD in Japan. 26944116

2016
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE The associations between rs823128/rs823156/rs708730 and PD are more likely to be replicated in Chinese and Malay populations. 25758099

2015
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
dbSNP: rs823156
rs823156
SLC41A1
A 0.850 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs823156
rs823156
SLC41A1
A 0.850 GeneticVariation GWASCAT Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs823156
rs823156
SLC41A1
0.850 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified several single-nucleotide polymorphisms (SNPs) at the PARK16 locus that can modulate the risk of Parkinson's disease (PD), including rs16856139, rs823128, rs823122, rs947211, rs823156, rs708730 and rs11240572. 21840748

2011
dbSNP: rs708730
rs708730
SLC41A1
0.720 GeneticVariation BEFREE The associations between rs823128/rs823156/rs708730 and PD are more likely to be replicated in Chinese and Malay populations. 25758099

2015
dbSNP: rs708730
rs708730
SLC41A1
0.720 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
dbSNP: rs708730
rs708730
SLC41A1
0.720 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs708730
rs708730
SLC41A1
0.720 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified several single-nucleotide polymorphisms (SNPs) at the PARK16 locus that can modulate the risk of Parkinson's disease (PD), including rs16856139, rs823128, rs823122, rs947211, rs823156, rs708730 and rs11240572. 21840748

2011
dbSNP: rs11240569
rs11240569
SLC41A1
0.020 GeneticVariation BEFREE The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population. 27612022

2016
dbSNP: rs11240569
rs11240569
SLC41A1
0.020 GeneticVariation BEFREE In this study, we confirmed that the C allele of SLC41A1 (rs11240569) polymorphism reduces the risk to develop sporadic PD (P = 0.018). 26308152

2015
dbSNP: rs1305279636
rs1305279636
SLC41A1
0.020 GeneticVariation BEFREE Here, we demonstrate that the substitution p.A350V potentially associated with PD is a gain-of-function mutation that enhances a core function of SLC41A1, namely Na⁺-dependent Mg²⁺ efflux by 69±10% under our experimental conditions (10-minute incubation in high-Na⁺ (145 mM) and completely Mg²⁺-free medium). 23976986

2013
dbSNP: rs1305279636
rs1305279636
SLC41A1
0.020 GeneticVariation BEFREE Two novel coding variants present only in the PD cohort were also identified within the RAB7L1 (p.K157R) and SLC41A1 (p.A350V) genes. 20683486

2010
dbSNP: rs373421823
rs373421823
SLC41A1
0.010 GeneticVariation BEFREE This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese PD. 24661466

2014