|
rs2064479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs2064479 in the HLA-DPB1 genetic region as being significantly associated with humoral immune response variations after rubella vaccination (P = 8.62 × 10(-8)).
|
25293367 |
2015 |
|
rs2284552
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses.
|
25139337 |
2014 |
|
rs2546893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses.
|
25139337 |
2014 |
|
rs669260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively).
|
25139337 |
2014 |
|
rs10774670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, two SNPs (rs3741981 and rs10774670) independently cross-regulated rubella virus-specific IL-10 secretion levels (p < or = 0.031).
|
20079393 |
2010 |
|
rs2660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele variants of three OAS1 SNPs (rs3741981/Ser162Gly, rs1051042/Thr361Arg, rs2660), located in a linkage disequilibrium block of functional importance, were significantly associated with an increase in rubella virus-specific IL-2/T(h)1 response (p <or = 0.024).
|
20079393 |
2010 |
|
rs2844482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002).
|
20923569 |
2010 |
|
rs2857708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002).
|
20923569 |
2010 |
|
rs3741981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, two SNPs (rs3741981 and rs10774670) independently cross-regulated rubella virus-specific IL-10 secretion levels (p < or = 0.031).
|
20079393 |
2010 |
|
rs4787947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002).
|
20923569 |
2010 |
|
rs7801617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002).
|
20923569 |
2010 |