Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ. 30181602

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism. 30472504

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ. 30181602

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism. 30472504

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia. 28864281

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE A significant association of rs6265 AA + AG × rs1799964 CC + CT with schizophrenia was observed (OR = 1.14, 95%CI: 1.02-1.27; P = .02). 29306772

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients.(PsycINFO Database Record 28857598

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms. 29595641

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations. 30312750

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients. 29898578

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia. 28864281

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients.(PsycINFO Database Record 28857598

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms. 29595641

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations. 30312750

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients. 29898578

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia. 27262112

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects. 27712141

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects. 27712141

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia. 27262112

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Studies have also shown that the BDNF Val66Met polymorphism was associated with weight gain in patients with schizophrenia on long-term antipsychotic treatment. 27483421

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia. 26603624

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Association of the brain-derived neurotrophic factor Val66Met polymorphism with negative symptoms severity, but not cognitive function, in first-episode schizophrenia spectrum disorders. 27668551

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia. 26889735

2016