|
rs61752717
|
|
C |
0.750 |
GeneticVariation |
GWASCAT |
Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis.
|
30946743 |
2019 |
|
rs61752717
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The present study indicates that the MEFV M694V mutation may contribute to the pathogenesis of AS.
|
28800602 |
2017 |
|
rs61752717
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Moreover, M694V is significantly associated with a</span> higher level of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in AS patients.
|
25036284 |
2014 |
|
rs61752717
|
|
|
0.750 |
GeneticVariation |
BEFREE |
A relatively higher frequency was observed for M694V mutation in AS patients than controls (10.7% versus 4.2% , p=0.060).
|
22960328 |
2012 |
|
rs61752717
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Therefore, association of M694V with ankylosing spondylitis can be recognized as a geographic region-specific risk factor affecting a common inflammatory pathway in the disease pathogenesis.
|
21695514 |
2011 |
|
rs61752717
|
|
|
0.750 |
GeneticVariation |
BEFREE |
M694V was the only variant that was significantly more common in the AS group than in the combined or individual control groups (P = 0.026 for AS patients versus healthy controls, P = 0.046 for AS patients versus RA patient controls, and P = 0.008 for AS patients versus healthy and RA patient control groups).
|
20533539 |
2010 |
|
rs3743930
|
|
|
0.030 |
GeneticVariation |
BEFREE |
But no significant differences were detected in either genotype or allele distributions between case and control groups for the polymorphism rs11466023 (P > .05).MEFV gene polymorphism rs3743930</span> might be significantly associated with AS susceptibility in Chinese Han population, and its G allele might predict high risk of AS.
|
30557972 |
2018 |
|
rs3743930
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of the current study was to determine the contributions of several common mutations in the Mediterranean fever (MEFV) gene, namely, E148Q, M680I, M694V and V726A, to ankylosing spondylitis (AS) susceptibility.
|
28800602 |
2017 |
|
rs3743930
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to analyze the association of common MEFV variations (M694V, M680I, V726A, and E148Q) with AS in a group of Turkish patients.
|
20669279 |
2010 |
|
rs11466023
|
|
|
0.020 |
GeneticVariation |
BEFREE |
But no significant differences were detected in either genotype or allele distributions between case and control groups for the polymorphism rs11466023 (P > .05).MEFV gene polymorphism rs3743930 might be significantly associated with AS susceptibility in Chinese Han population, and its G allele might predict high risk of AS.
|
30557972 |
2018 |
|
rs28940579
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of the current study was to determine the contributions of several common mutations in the Mediterranean fever (MEFV) gene, namely, E148Q, M680I, M694V and V726A, to ankylosing spondylitis (AS) susceptibility.
|
28800602 |
2017 |
|
rs11466023
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations (M694V, M680I, V726A, E148Q and P369S) in a cohort of Turkish patients with AS.
|
22960328 |
2012 |
|
rs28940579
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to analyze the association of common MEFV variations (M694V, M680I, V726A, and E148Q) with AS in a group of Turkish patients.
|
20669279 |
2010 |
|
rs224204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AS patients with PA showed an earlier age of disease onset (p=0.021), longer disease duration (p=0.020) and longer duration of AS symptoms from onset (p=0.034) than AS patients without PA. We found significant associations with the presence of PA at disease onset in 14 SNPs located in 10 genes: HLA-DQB2 (rs2857210 and rs9276615), HLA-DOB (rs2857151, rs2621332 and rs1383261), JAK2 (rs7857730), IL-23R (rs11209008 and rs10489630), CYP1B1 (rs1056836), NELL1 (rs8176786), KL (rs564481), and MEFV (rs224204), IL-2RB (rs743777) and IL-1A (rs1800587).
|
30299251 |
2019 |