|
rs56149945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for the N</span>363S variant in PTSD, at 5.1% was not more prevalent than in other population studies of the N363S polymorphism in Caucasians (6.0-14.8%).
|
15511603 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
rs9470080
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although FKBP5 SNPs did not directly predict PTSD symptom outcome or interact with level of non-child abuse trauma to predict PTSD symptom severity, 4 SNPs in the FKBP5 locus significantly interacted (rs9296158, rs3800373, rs1360780, and rs9470080; minimum P = .0004) with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing.
|
18349090 |
2008 |
|
rs9296158
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Although FKBP5 SNPs did not directly predict PTSD symptom outcome or interact with level of non-child abuse trauma to predict PTSD symptom severity, 4 SNPs in the FKBP5 locus significantly interacted (rs9296158, rs3800373, rs1360780, and rs9470080; minimum P = .0004) with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing.
|
18349090 |
2008 |
|
rs6277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.
|
18833581 |
2009 |
|
rs4606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure.
|
19162436 |
2009 |
|
rs4680
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The present findings indicate a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.
|
19944409 |
2010 |
|
rs562010289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the frequency of the substance P receptor (TACR1) 1354 G>C polymorphism in FMS.The dopamine transporter (DAT) SLC6A3 3' variable number tandem repeat (VNTR) polymorphism is associated with post traumatic stress disorder (PTSD), a condition with clinical and epidemiological overlap with FMS.
|
20074437 |
2010 |
|
rs9470080
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In AAs, one of the SNPs, rs9470080, moderated the risk of PTSD that was associated with childhood abuse.
|
20393453 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this paper is to review the available knowledge on the BDNF Val66Met SNP, with emphasis on anxiety- and fear-related endophenotypes and its potential implications for PTSD.
|
20955337 |
2010 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this paper is to review the available knowledge on the BDNF Val66Met SNP, with emphasis on anxiety- and fear-related endophenotypes and its potential implications for PTSD.
|
20955337 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of the present study was to identify, in a case-control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence.
|
21491204 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of the present study was to identify, in a case-control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence.
|
21491204 |
2011 |
|
rs12944712
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results indicated that multiple SNPs were associated with acute symptoms at a univariate level, and after correction for multiple testing, rs12944712 was significantly related to acute PTSD symptoms.
|
21508513 |
2011 |
|
rs9296158
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In our endocrine study, we found that only risk allele A carriers of rs9296158 showed GR supersensitivity with PTSD; in contrast, baseline cortisol levels were decreased in PTSD only in patients with the GG genotype.
|
21536970 |
2011 |
|
rs25531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated whether SLC6A4 promoter polymorphisms (5-HTTLPR, rs25531) and several downstream single nucleotide polymorphisms (SNPs) modulated activity of brain regions involved in the cognitive control of emotion in post-9/11 veterans with PTSD.
|
21545724 |
2011 |
|
rs16965628
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SLC6A4 SNP rs16965628 and 5-HTTLPR are associated with a bias in neural responses to traumatic reminders and cognitive control of emotions in patients with PTSD.
|
21545724 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD.
|
21728904 |
2012 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD.
|
21728904 |
2012 |
|
rs4680
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our findings suggest Val158Met genotype moderates the effect of PTSD-related processes on right ACC volume.
|
21783175 |
2011 |
|
rs25531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There were significant intergroup (PTSD versus non-PTSD) differences in the genotype frequencies of 5-HTTLPR/rs25531 (χ(2) [1, n = 388] = 16.23, P = 5.62 × 10(-5) ).
|
21818827 |
2011 |
|
rs25531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that although the STin2 variant and 5-HTTLPR alone did not associate with increased PTSD symptoms, rs25531 and the 5-HTTLPR multimarker genotype (combined 5-HTTLPR and rs25531) were associated with significantly increased acute stress disorder symptoms at 2 to 4 weeks postshooting (n = 161; P < .05).
|
21893641 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |