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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Several studies on genetic variants of methylenetetrahydrofolate reductase (MTHFR, which plays a crucial role in regulation of plasma homocysteine concentration) reported an association between C677T gene polymorphism and stroke in some Asian populations.
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19193985 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects.
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19717029 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We conclude that the MTHFR 677C>T polymorphism may be considered as a genetic risk factor of childhood stroke, especially in boys.
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19805823 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The aim of this study is to determine the role of hereditary thrombophilic factors including factor V Leiden A1691G (FVL), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations in patients with stroke because of cerebral infarct.
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19263510 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
A significant combined effect on stroke due to the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR), the T2354A polymorphism of 5-lipoxygenase activating protein (ALOX5AP), and Lp(a) level, was detected using the MDR method.
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17521309 |
2007 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The sensitivity analysis (exclusion of studies with controls not in Hardy-Weinberg equilibrium) revealed a significant association of stroke with the MTHFR C677T and ApoE epsilon 4 alleles but showed no association with ACE gene insertion/deletion polymorphism.
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17171228 |
2007 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Therefore, we examined whether the C677T and A1298C polymorphisms of MTHFR gene are genetic risk factors for both ischemic and hemorrhagic stroke in a Turkish Caucasian population.
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17113927 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke.
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16365871 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Plasma total homocysteine (tHcy) concentration and the distribution of the C677T genotypes of the methylenetetrahydrofolate reductase gene (MTHFR) were compared in 174 consecutive patients with stroke aged <45 years and 155 age and sex-matched controls.
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16624841 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant.
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16814086 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to hyperhomocysteinemia and increase the risk factor for stroke.
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16629766 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In view of the prevailing controversy about the role of Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in stroke and paucity of studies from India, this study has been undertaken to evaluate MTHFR C677T gene polymorphism in consecutive ischemic stroke patients and correlate these with folic acid, homocysteine (Hcy) and conventional risk factors.
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16936384 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We present a case of a child with bidirectional Glenn anastomosis for double inlet left ventricle that suffered a stroke despite aspirin prophylaxis; the patient was combined homozygous for prothrombin G20210A mutation and for methylenetetrahydrofolate reductase C677T mutation as well.
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16209893 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043).
|
16053469 |
2005 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
This indicates that C677T MTHFR mutation is strongly associated with arterial stroke especially in young adults.
|
15613145 |
2005 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke.
|
15652605 |
2005 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
A recent study of children demonstrated that the homozygous form of C677T polymorphism occurred two-times as often in those with stroke versus healthy controls.
|
16282888 |
2005 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.
|
14693836 |
2004 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Genotyping of methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and brain MRI examination were performed in 1721 subjects free of any history of stroke.
|
12690212 |
2003 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
It is still controversial whether elevated plasma homocysteine and the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene are risk factors for stroke.
|
12907815 |
2003 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Fasting total plasma homocysteine (tHcy) concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype were determined in 25 patients with sCAD, 31 patients <45 years of age with non-CAD ischemic stroke, and 36 control subjects.
|
11872884 |
2002 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We investigated associations between the C677T MTHFR polymorphism, folate levels, total plasma homocysteine, and hematological parameters in 94 patients with cerebrovascular disease (transient ischemic attack/minor stroke) and in 82 healthy subjects.
|
10695265 |
2000 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Moreover, the 677 C-->T genotype is a strong factor for predisposition to hyperhomocysteinemia and recurrent risk of stroke</span> that might also be prevented with folate supplementation.
|
10830195 |
2000 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The roles of ACE D polymorphism and the MTHFR C677T mutation in stroke, should also be taken into consideration in this subgroup of stroke patients.
|
10949530 |
2000 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
According to our results, the C677T mutation does not constitute a major risk factor for transient ischemic attack or minor stroke, even under consideration of other possibly confounding factors that are known to affect plasma homocysteine levels.
|
10360632 |
1999 |