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rs10507391
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD.
|
26944113 |
2016 |
|
rs10507391
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The interaction between rs10507391 and rs776746 increases the susceptibility to ischemic stroke and is associated with atherothrombotic events in stroke patients.
|
25534367 |
2015 |
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rs10507391
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Eight variants in five candidate genes were examined for the risk of stroke, including the SG13S32 (rs9551963), SG13S42 (rs4769060), SG13S89 (rs4769874), and SG13S114 (rs10507391) variants of the 5-lipoxygenase activating protein (ALOX5AP) gene, the G860A (rs751141) variant of the soluble epoxide hydrolase (EPHX2) gene, the A1075C (rs1057910) variant of the CYP2C9*2 gene, the C430T (rs1799853) variant of the CYP2C9*3 gene, and the A6986G (rs776746) variant of the CYP3A5 gene.
|
24368493 |
2014 |
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rs10507391
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Haplotype-based association analysis of block 2 involving rs10507391 and rs12429692 revealed that the decreased risk of stroke was significantly associated with haplotype AA (OR, 0.66; 95% CI, 0.46-0.95).
|
21153769 |
2011 |
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rs9551963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that only the ALOX5AP gene, and specifically the rs9551963 and rs4769060 genotypes, exhibited significantly different distributions between the stroke and control groups in female participants.
|
24485247 |
2015 |
|
rs9551963
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Eight variants in five candidate genes were examined for the risk of stroke, including the SG13S32 (rs9551963), SG13S42 (rs4769060), SG13S89 (rs4769874), and SG13S114 (rs10507391) variants of the 5-lipoxygenase activating protein (ALOX5AP) gene, the G860A (rs751141) variant of the soluble epoxide hydrolase (EPHX2) gene, the A1075C (rs1057910) variant of the CYP2C9*2 gene, the C430T (rs1799853) variant of the CYP2C9*3 gene, and the A6986G (rs776746) variant of the CYP3A5 gene.
|
24368493 |
2014 |
|
rs17222919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that ALOX5AP-rs17222919-1316T/G may be a protective factor aginst stroke.
|
30313062 |
2018 |
|
rs4769060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that only the ALOX5AP gene, and specifically the rs9551963 and rs4769060 genotypes, exhibited significantly different distributions between the stroke and control groups in female participants.
|
24485247 |
2015 |
|
rs3803277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results were indicative of a protective role of the three SNPs either in homozygosity or heterozygosity for MAF and more specifically rs3803277: CA/AA genotypes were protective against SVO stroke subtype.
|
25010723 |
2014 |
|
rs12429692
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype-based association analysis of block 2 involving rs10507391 and rs12429692 revealed that the decreased risk of stroke was significantly associated with haplotype AA (OR, 0.66; 95% CI, 0.46-0.95).
|
21153769 |
2011 |
|
rs9579646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the single-locus analysis, we found that the rs9579646 AG genotype was associated with a marginally decreased risk for stroke (adjusted odds ratio, 0.65; 95% confidence interval, 0.45-0.96), compared with the AA genotype.
|
21153769 |
2011 |