|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We assessed associations of GDM related genetic variants in/near the CDKAL1 (rs7754840) and MTNR1B (rs10830962) genes with changes in fasting levels of glucose and insulin, β-cell function (HOMA-B) and insulin resistance (HOMA-IR) at 1 year and 2 years after the baseline.
|
31542245 |
2019 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that two SNPs in particular(rs7754840 and rs7756992 in CDKAL1) were very strongly associated with GDM risk.
|
30074065 |
2018 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The most important risk alleles associated with GDM were rs10830963/G of MTNR1B (OR = 1.84/1.64 [IADPSG/m'99WHO], p = 0.0007/0.006), rs7754840/C (OR = 1.51/NS, p = 0.016) of CDKAL1 and rs1799884/T (OR = 1.4/1.56, p = 0.04/0.006) of GCK.
|
28072873 |
2017 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs7754840 and rs7756992 SNPs of the CDKAL1 gene were found to be associated with GDM in this south Indian population.
|
25723968 |
2015 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in CDKAL1, had the strongest association with GDM (odds ratio 1.518; P=6.65×10(-16)).
|
22233651 |
2012 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We also found that the risk alleles of rs2383208 (b = -0.085, p = 0.003), rs4402960 (b = -0.057, p = 0.046) and rs10830963 (b = -0.096, p = 0.001) were associated with HOMA-B, while rs7754840 was associated with decrease in insulin AUC during a 100 g OGTT given at the time of GDM diagnosis (b = -0.080, p = 0.007).
|
22096510 |
2011 |
|
rs7754840
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Compared with controls (men and women combined), GDM</span> was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2.
|
19002430 |
2009 |
|
rs10830962
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Association of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population.
|
30926842 |
2019 |
|
rs10830962
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We assessed associations of GDM related genetic variants in/near the CDKAL1 (rs7754840) and MTNR1B (rs10830962) genes with changes in fasting levels of glucose and insulin, β-cell function (HOMA-B) and insulin resistance (HOMA-IR) at 1 year and 2 years after the baseline.
|
31542245 |
2019 |
|
rs10830962
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The rs10830962 polymorphism in MTNR1B was not associated with an increased risk of developing GDM or any of the clinical or metabolic characteristics in patients with GDM (p > 0.05).
|
24157813 |
2013 |
|
rs10830962
|
|
|
0.840 |
GeneticVariation |
BEFREE |
A variant near MTNR1B, rs10830962, was also significantly associated with the risk of GDM (1.454; P=2.49×10(-13)).
|
22233651 |
2012 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.
|
31808503 |
2019 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, rs10830963 may tag a molecular mechanism leading to insulin resistance in Han Chinese women with GDM.
|
29656698 |
2019 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that <i>MTNR1B</i> rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.
|
30991439 |
2019 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings of this study suggest that rs10830963 and rs7936247 may be markers for susceptibility to GDM in a Chinese population.
|
30912250 |
2019 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results provide evidence that the T risk allele in TCF7L2 rs7903146 is associated with failure in early postprandial glycemic control and requirement of insulin therapy in women with gestational diabetes mellitus, even after adjusting for confounding factors such BMI and age.
|
31546272 |
2019 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The established circadian rhythm-associated MTNR1B genetic variant (rs10830963) was genotyped in 1025 Chinese women with a history of GDM.
|
29590381 |
2018 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carrying the <i>MTNR1B</i> rs10830963/<i>G</i> risk allele-in interaction with pre-pregnancy BMI-is likely be considered as a candidate pharmacogenetic marker of antenatal insulin therapy initiation and should be further assessed in precision medicine trials in GDM.
|
30477160 |
2018 |
|
rs10830963
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk.
|
29947923 |
2018 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs1801282 polymorphism may not be associated with genetic susceptibility to GDM in whites.
|
29885389 |
2018 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the additional presence of TCF7L2 rs7903146 risk alleles does not further aggravate the negative impact of a history of gestational diabetes on metabolic traits related to T2DM.
|
30419301 |
2018 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic variant rs7903146 (C > T) in TCF7L2 gene showed a strong association with GDM risk (OR: 2.56; 95% CI: [1.24-5.29]).
|
29325775 |
2018 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the first time, we identified eight variants associated with GDM, namely rs7957197 (HNF1A), rs10814916 (GLIS3), rs3802177 (SLC30A8), rs9379084 (RREB1), rs34872471 (TCF7L2), rs7903146 (TCF7L2), rs11787792 (GPSM1) and rs7041847 (GLIS3).
|
29947923 |
2018 |