|
rs10046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed that rs700518 and rs10046, as well as a haplotype constructed with rs1870049 and rs10046, in the human CYP19A1 gene can be used as genetic markers for gender-specific EH.
|
18274619 |
2008 |
|
rs1012841819
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Constitutively activated GRK4 gene variants (R65L, A142V, and A486V), by themselves or by their interaction with other genes involved in blood pressure regulation, are associated with essential hypertension and/or salt-sensitive hypertension in several ethnic groups.
|
20153824 |
2010 |
|
rs1012841819
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations.
|
25732908 |
2016 |
|
rs10199956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the haplotype-based case-control analysis revealed that there was a significant difference between the EH and NT groups with regard to overall distribution of the allele combinations at three SNPs-rs3754701-rs3769048-rs10199956-(P=0.002).
|
28181496 |
2017 |
|
rs1021737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study suggests that the SNPs rs482843 and rs1021737 of the CTH gene were not associated with essential hypertension in the Northern Chinese Han population.
|
18701025 |
2008 |
|
rs1024323
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls.
|
17044852 |
2006 |
|
rs1024323
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations.
|
25732908 |
2016 |
|
rs1024323
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Constitutively activated GRK4 gene variants (R65L, A142V, and A486V), by themselves or by their interaction with other genes involved in blood pressure regulation, are associated with essential hypertension and/or salt-sensitive hypertension in several ethnic groups.
|
20153824 |
2010 |
|
rs1037733674
|
|
|
0.020 |
GeneticVariation |
BEFREE |
1.Previous glucagon receptor gene (GCGR) studies have shown a Gly40Ser mutation to be more prevalent in essential hypertension and to affect glucagon binding affinity to its receptor.
|
9673441 |
1998 |
|
rs1037733674
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population.
|
10090412 |
1999 |
|
rs1042713
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese.
|
15554460 |
2004 |
|
rs1042713
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We detected an association between EDNRB rs5351, VEGFA -2549(18)I/D, and ADRB2 rs1042713 polymorphisms and essential hypertension in men of Tatar ethnic origin.
|
28350619 |
2017 |
|
rs1042713
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No consensus has been reached on the association between the β2-adrenergic receptor polymorphisms A46G and C79G and essential hypertension risk.
|
20739939 |
2010 |
|
rs1042713
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH).
|
12361188 |
2002 |
|
rs1042713
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We revealed that the ADRB2 A46G polymorphism might increase the risk for EH in the Northern Han Chinese population.
|
21483652 |
2011 |
|
rs1042714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No consensus has been reached on the association between the β2-adrenergic receptor polymorphisms A46G and C79G and essential hypertension risk.
|
20739939 |
2010 |
|
rs1042714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No significant association could be found between C-47T or C79G polymorphism and EH risk.
|
21483652 |
2011 |
|
rs1043210477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study.
|
21053180 |
2010 |
|
rs1047047
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the EH group than in the NT1 group (p<0.0001) or the NT2 group (p<0.0001).
|
18037771 |
2007 |
|
rs1047303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs6203 and rs1047303 in the HSD3B1 gene are useful genetic markers for EH, while polymorphisms of HSD3B1 are associated with the BP and aldosterone level.
|
20660004 |
2010 |
|
rs1048829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> The SNPs of the rs6435156 and rs1048829 locus in the <i>BMPR2</i> gene, the rs121909287 loci in the <i>ACVRL1</i> gene, and the rs397514716 locus in the <i>SMAD9</i> gene were associated with a risk of EH in Han Chinese.
|
30617053 |
2019 |
|
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The best MDR model associated with EH risk included rs1048943, rs762551, rs1056836, and cigarette smoking (cross-validation consistency 100%, prediction error 45.7%, Ppermutation<0.0001).
|
27977510 |
2017 |
|
rs10501367
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The data suggest that APLNR rs7119375 and rs10501367 are associated with a decreased risk of essential hypertension in our Mexican-Mestizo studied group, but further studies are warranted.
|
27450650 |
2016 |
|
rs10501367
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two polymorphisms [rs3761581 (A/C) and T-1860C] in apelin gene and two [rs7119375 (G/A), rs10501367 (G/A)] in AGTRL1 gene were genotyped using the TaqMan assay among 969 patients diagnosed with essential hypertension and 980 age and sex-matched controls.
|
20485192 |
2010 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH).
|
22158110 |
2012 |