Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.040 | GeneticVariation | BEFREE | MTHFR gene polymorphisms, the c. 677C>T and c. 1298A>C have been implicated as risk factors for several types of cancers as the acute leukemia. | 28374953 | 2018 |
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0.040 | GeneticVariation | BEFREE | This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. | 22706675 | 2012 |
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0.040 | GeneticVariation | BEFREE | The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population. | 17970089 | 2007 |
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0.040 | GeneticVariation | BEFREE | We retrospectively analyzed the incidence of MTHFR C677T and the influence of genotype on methotrexate (MTX) toxicity in patients with acute leukemia undergoing maintenance chemotherapy. | 12453860 | 2002 |
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0.020 | GeneticVariation | BEFREE | This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. | 22706675 | 2012 |
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0.020 | GeneticVariation | BEFREE | The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population. | 17970089 | 2007 |
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|
0.010 | GeneticVariation | BEFREE | This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. | 22706675 | 2012 |
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|
0.010 | GeneticVariation | BEFREE | This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. | 22706675 | 2012 |