|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
|
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
|
rs121434569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T790M detection was associated with higher number of new progressing sites (P = .04), liver progression (P = .002), and a lower frequency of lung metastases (P = .027).
|
31601525 |
2020 |
|
rs121909222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, following tail vein injection, both Pten(∆):p53(R270H) spindle and PDA tumor cells induced lung metastases and morbidity significantly faster than Pten(∆):p53(∆) double-deletion cells, and this was associated with the ability of Pten(∆):p53(R270H) tumor cells to upregulate E-cadherin expression in lung metastases.
|
26781438 |
2016 |
|
rs121913227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In melanoma, V600K mutations in comparison to other BRAF mutations were associated with more frequent brain (75% vs. 36.3%, p = 0.02) and lung metastases (91.6% vs. 47.7%, p = 0.007), and shorter time from diagnosis to metastasis and to death (19 vs. 53 months, p = 0.046 and 78 vs. 322 months, p = 0.024 respectively).
|
22039425 |
2011 |
|
rs121913499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A somatic, heterozygous IDH1 c.C394T (p.R132C) mutation was identified in one human melanoma metastasis to the lung.
|
20603105 |
2010 |
|
rs121913529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The codon 12 G12D mutation was found; the same mutation was evident in the primary cancer of the colon and in its liver and lung metastasis.
|
20213843 |
2010 |
|
rs139883133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, overexpression of LMCD1 E135K mutation significantly promoted systemic lung metastasis in a murine tail vein injection model.
|
21996735 |
2012 |
|
rs1430452530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
|
rs1989839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs1989839C/T is also associated with the Enneking stage of osteosarcoma and risk of lung metastasis.
|
27880743 |
2016 |
|
rs201701502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model.
|
28676216 |
2017 |