|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
|
rs121913529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The codon 12 G12D mutation was found; the same mutation was evident in the primary cancer of the colon and in its liver and lung metastasis.
|
20213843 |
2010 |
|
rs767808984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The codon 12 G12D mutation was found; the same mutation was evident in the primary cancer of the colon and in its liver and lung metastasis.
|
20213843 |
2010 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
|
rs121913499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A somatic, heterozygous IDH1 c.C394T (p.R132C) mutation was identified in one human melanoma metastasis to the lung.
|
20603105 |
2010 |
|
rs770374782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A somatic, heterozygous IDH1 c.C394T (p.R132C) mutation was identified in one human melanoma metastasis to the lung.
|
20603105 |
2010 |
|
rs139883133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, overexpression of LMCD1 E135K mutation significantly promoted systemic lung metastasis in a murine tail vein injection model.
|
21996735 |
2012 |
|
rs121913227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In melanoma, V600K mutations in comparison to other BRAF mutations were associated with more frequent brain (75% vs. 36.3%, p = 0.02) and lung metastases (91.6% vs. 47.7%, p = 0.007), and shorter time from diagnosis to metastasis and to death (19 vs. 53 months, p = 0.046 and 78 vs. 322 months, p = 0.024 respectively).
|
22039425 |
2011 |
|
rs1430452530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
|
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
|
rs762959475
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
|
rs754533102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By introduction of gene Msurvivin T34A in combination with chemotherapies in the treatment of lung metastasis tumor, it could greatly reduce systemic toxicity as well as improved the anti-tumor efficiency.
|
24582554 |
2014 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
|
rs121909222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, following tail vein injection, both Pten(∆):p53(R270H) spindle and PDA tumor cells induced lung metastases and morbidity significantly faster than Pten(∆):p53(∆) double-deletion cells, and this was associated with the ability of Pten(∆):p53(R270H) tumor cells to upregulate E-cadherin expression in lung metastases.
|
26781438 |
2016 |
|
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |