| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | BEFREE | The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent major genetic risk factors for progressive liver injury in nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and chronic viral hepatitis. | 30161167 | 2018 |
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|
0.090 | GeneticVariation | BEFREE | Our case-control study confirmed that PNPLA3 rs738409 SNP is associated with ALD. | 29474507 | 2018 |
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|
0.090 | GeneticVariation | BEFREE | In a Han Chinese population, the present study confirmed that PNPLA3 polymorphism rs738409 was more likely to influence the susceptibility to ALD. | 30132178 | 2018 |
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|
0.090 | GeneticVariation | BEFREE | PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC. | 25964223 | 2015 |
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|
0.090 | GeneticVariation | BEFREE | Genetic testing of the I148M genotype in ALD patients awaiting liver transplantation might be beneficial for these patients. | 25273282 | 2014 |
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|
0.090 | GeneticVariation | BEFREE | We performed a systematic review of previous studies on the relationship between rs738409 of PNPLA3 and ALD and meta-analysis was conducted in a random-effects model. | 25060292 | 2014 |
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|
0.090 | GeneticVariation | BEFREE | The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with non-alcoholic fatty liver disease and alcoholic liver disease (ALD). | 22869157 | 2013 |
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|
0.090 | GeneticVariation | BEFREE | The finding of an additive interaction among rs738409, obesity, and alcohol towards NAS may be useful in targeting preventative care to patients at highest risk for ALD. | 23032985 | 2012 |
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|
0.090 | GeneticVariation | BEFREE | In European Caucasians, the rs738409 variant is associated with increased risk of ALD, liver damage, and cirrhosis. | 21334404 | 2011 |