rs1466535
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our work supports the evidence that the T allele of the rs1466535 LRP1 polymorphism is an independent risk factor for abdominal aortic aneurysm.
|
24423473 |
2015 |
rs1466535
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Genetic polymorphisms all previously reported as showing a significant correlation with AAA with functional effects on the expression or function were determined by analysis of the genomic DNA, including angiotensin 1 receptor (rs5186), interleukin-10 (IL-10; rs1800896), methyl-tetrahydrofolate reductase (rs1801133), low-density lipoprotein receptor-related protein 1 (LRP1; rs1466535), angiotensin-converting enzyme (rs1799752), and several matrix metalloproteinase 9 (MMP-9) single nucleotide polymorphisms.
|
24801553 |
2014 |
rs1466535
|
|
|
0.840 |
GeneticVariation |
BEFREE |
An association between rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and abdominal aortic aneurysm (AAA) was recently demonstrated.
|
25238221 |
2014 |
rs1466535
|
|
C |
0.840 |
GeneticVariation |
GWASDB |
No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA.
|
22055160 |
2011 |
rs1466535
|
|
|
0.840 |
GeneticVariation |
BEFREE |
No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA.
|
22055160 |
2011 |
rs1466535
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA.
|
22055160 |
2011 |
rs6511720
|
|
T |
0.810 |
GeneticVariation |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |
rs6511720
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
LDLR rs6511720 is associated with AAA.This finding is consistent with established effects of this variant on coronary artery disease.
|
24046328 |
2013 |
rs6511720
|
|
|
0.810 |
GeneticVariation |
GWASDB |
LDLR rs6511720 is associated with AAA.This finding is consistent with established effects of this variant on coronary artery disease.
|
24046328 |
2013 |
rs6511720
|
|
|
0.810 |
GeneticVariation |
BEFREE |
LDLR rs6511720 is associated with AAA.This finding is consistent with established effects of this variant on coronary artery disease.
|
24046328 |
2013 |
rs7025486
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10).
|
20622881 |
2010 |
rs7025486
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10).
|
20622881 |
2010 |
rs7025486
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10).
|
20622881 |
2010 |
rs2383207
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
|
20622881 |
2010 |
rs2383207
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
|
20622881 |
2010 |
rs2836411
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Associations between rs9316871and rs2836411 and AAA risk were replicated in the meta-analysis of the two independent cohorts, providing further support for the importance of these loci in the aetiology of AAA.
|
31680049 |
2020 |
rs2836411
|
|
|
0.720 |
GeneticVariation |
BEFREE |
ERG is involved in vascular development, angiogenesis, and inflammation in atherosclerosis, therefore mechanistically, rs2836411 could contribute to AAA by modulating ERG levels.
|
31691800 |
2020 |
rs2836411
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |
rs1795061
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In ARIC, rs9316871 and rs3827066 were significantly associated with AAA risk (HR [p] was 0.77 [.004] and 1.22 [.03], respectively), rs2836411 was associated at borderline significance (1.13 [.08]), whereas rs1795061 was not associated (p = .55).
|
31680049 |
2020 |
rs9316871
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In ARIC, rs9316871 and rs3827066 were significantly associated with AAA risk (HR [p] was 0.77 [.004] and 1.22 [.03], respectively), rs2836411 was associated at borderline significance (1.13 [.08]), whereas rs1795061 was not associated (p = .55).
|
31680049 |
2020 |
rs1795061
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |
rs9316871
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |
rs3019885
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The prevalence of carriers of the rs3019885 SLC30A8 G allele was higher in control subjects (67.8%) than in patients (60.3%, P = .022), suggesting a protective effect for AAA.
|
24423473 |
2015 |
rs3019885
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
|
22055160 |
2011 |
rs10757274
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
|
27899403 |
2017 |