|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction.
|
17392738 |
2007 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans.
|
23319002 |
2013 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
|
27521573 |
2016 |
|
rs63751273
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.
|
28634382 |
2017 |
|
rs63751273
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study was undertaken to examine whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation.
|
28269786 |
2017 |
|
rs63751273
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Forebrain-specific over-expression of human tau(P301L), a mutation associated with frontotemporal dementia with parkinsonism linked to chromosome 17, in rTg4510 mice results in the formation of NFTs, learning and memory impairment and massive neuronal death.
|
22027994 |
2012 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
|
27521573 |
2016 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction.
|
17392738 |
2007 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans.
|
23319002 |
2013 |
|
rs104893877
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A53T mice also exhibit spatial memory deficits at 6 and 12 months, as demonstrated by Y-maze performance.
|
23936403 |
2013 |
|
rs104893877
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results directly implicate tau as a mediator of specific human mutant A53T αS-mediated abnormalities related to deficits in hippocampal neurotransmission and suggest a mechanism for memory impairment that occurs as a consequence of synaptic dysfunction rather than synaptic or neuronal loss.
|
31168644 |
2019 |
|
rs281865071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor.
|
18534914 |
2008 |
|
rs281865071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits.
|
15964197 |
2005 |
|
rs4680
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The COMT val(158)met polymorphism was associated with abstinence-related working memory deficits in two independent samples of smokers.
|
23828159 |
2013 |
|
rs4680
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
|
17113268 |
2007 |
|
rs63750264
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously showed that mice over-expressing a human mutated form of APP (APP(V717F)) display age-dependent recognition memory deficits associated with the progression of amyloid deposition.
|
10718322 |
2000 |
|
rs63750264
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Tg-APP (Sw, V717F)/B6 mice at 11-14 months displayed decreased motor coordination, learning and memory deficits, and severely increased anxiety.
|
15114629 |
2004 |
|
rs63750424
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.
|
12368474 |
2002 |
|
rs63750424
|
|
|
0.020 |
GeneticVariation |
BEFREE |
R406W patients often show a long course of disease with marked memory deficits.
|
29370822 |
2018 |
|
rs11136000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD.
|
26899953 |
2016 |
|
rs11142387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.
|
27923415 |
2017 |
|
rs12273363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI.
|
28755387 |
2018 |
|
rs1397094538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a causal role for T158A mutation in the development of RTT-like phenotypes, including developmental regression, motor dysfunction, and learning and memory deficits.
|
22119903 |
2011 |
|
rs1411832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On associating quantitative DMS-TC with interactive variables of groups × genotype, one SNP (rs1411832), located downstream of YWHAZP5 in chromosome 10, was found to be associated with the working memory deficit in schizophrenia patients with lowest p-value (p = 2.02 × 10(-7)).
|
25608650 |
2015 |
|
rs1424266770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
|
24439478 |
2014 |