|
rs3851179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020).
|
29883038 |
2019 |
|
rs744373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Together, our findings suggest that the BIN1 rs744373 SNP is associated with increased tau but not beta-amyloid pathology, suggesting that alterations in BIN1 may contribute to memory deficits via increased tau pathology.
|
30992433 |
2019 |
|
rs767543900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results directly implicate tau as a mediator of specific human mutant A53T αS-mediated abnormalities related to deficits in hippocampal neurotransmission and suggest a mechanism for memory impairment that occurs as a consequence of synaptic dysfunction rather than synaptic or neuronal loss.
|
31168644 |
2019 |
|
rs12273363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI.
|
28755387 |
2018 |
|
rs536551654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic reduction of p75NTR in P301L mice rescued the memory deficits, alleviated tau hyperphosphorylation and restored the activity of the AKT/GSK3β pathway.
|
29867188 |
2018 |
|
rs63750577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical phenotype was consistent regarding initial memory impairment and early onset in the late twenties found in all S170F patients.
|
29466804 |
2018 |
|
rs7127507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI.
|
28755387 |
2018 |
|
rs713041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the GPX4 rs713041, the frequency of the TT genotype was higher in the group with normal scores than in the group with long-term visual memory deficits (p = 0.025).
|
29246792 |
2018 |
|
rs11142387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.
|
27923415 |
2017 |
|
rs74315408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report the first case of V180I rare mutation in a Brazilian woman whose clinical condition started with memory impairment for recent events and insomnia with 2 months of evolution, without any other alterations in neurological examination.
|
29095671 |
2017 |
|
rs775129479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In TUBA4A, we detected a novel frameshift mutation (p.Arg64Glyfs*90) leading to a truncated protein in 1 FTD patient (1/459 of 0.22%) with family history of Parkinson's disease and cognitive impairment, and a novel missense mutation (p.Thr381Met) in 2 sibs with familial ALS and memory problems (1 index patient/429, 0.23%) in whom we previously identified a pathogenic Chromosome 9 open reading frame 72 repeat expansion mutation.
|
28069311 |
2017 |
|
rs781587642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In TUBA4A, we detected a novel frameshift mutation (p.Arg64Glyfs*90) leading to a truncated protein in 1 FTD patient (1/459 of 0.22%) with family history of Parkinson's disease and cognitive impairment, and a novel missense mutation (p.Thr381Met) in 2 sibs with familial ALS and memory problems (1 index patient/429, 0.23%) in whom we previously identified a pathogenic Chromosome 9 open reading frame 72 repeat expansion mutation.
|
28069311 |
2017 |
|
rs11136000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD.
|
26899953 |
2016 |
|
rs1411832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On associating quantitative DMS-TC with interactive variables of groups × genotype, one SNP (rs1411832), located downstream of YWHAZP5 in chromosome 10, was found to be associated with the working memory deficit in schizophrenia patients with lowest p-value (p = 2.02 × 10(-7)).
|
25608650 |
2015 |
|
rs763868966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a novel nonsense mutation (c.1000 G>T, p.(Glu312Ter); also termed p.(E312*)</span>) within a rod domain of GFAP in a 67-year-old Korean man with a history of memory impairment and leukoencephalopathy.
|
24755947 |
2015 |
|
rs1424266770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
|
24439478 |
2014 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
|
24439478 |
2014 |
|
rs63750852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data demonstrated that human Val97Leu mutant presenilin-1 causes spatial memory deficit in mice and increases tau phosphorylation level in glycogen synthase kinase-3-dependent manner.
|
21929538 |
2012 |
|
rs1397094538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a causal role for T158A mutation in the development of RTT-like phenotypes, including developmental regression, motor dysfunction, and learning and memory deficits.
|
22119903 |
2011 |
|
rs61748411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a causal role for T158A mutation in the development of RTT-like phenotypes, including developmental regression, motor dysfunction, and learning and memory deficits.
|
22119903 |
2011 |
|
rs8074995
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism (SNP) rs8074995 lies within the PRKCA region spanned by a rare haplotype associated with schizophrenia in a recent UK study and provides further evidence of PRKCA contribution to memory impairment and susceptibility to schizophrenia.
|
21281445 |
2011 |
|
rs6277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
|
17113268 |
2007 |
|
rs781049584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks.
|
15006688 |
2004 |
|
rs17125721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment.
|
11755019 |
2002 |
|
rs572842823
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recently described mouse line, Tg(HuAPP695.K670N/M671L)2576, expressing human amyloid precursor protein with a familial AD gene mutation, age-related amyloid deposits, and memory deficits, was found to develop a significant microglial response using Griffonia simplicifolia lectin or phosphotyrosine probe to identify microglia Both Griffonia simplicifolia lectin and phosphotyrosine staining showed increased numbers of intensely labeled, often enlarged microglia clustered in and around plaques, consistent with microglial activation related to beta-amyloid formation.
|
9422548 |
1998 |