rs121913529
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
rs121913529
|
|
|
0.740 |
GeneticVariation |
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
|
30876538 |
2019 |
rs121913529
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer.
|
21734707 |
2011 |
rs121913529
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
|
14706336 |
2003 |
rs121913529
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
|
|
|
rs121913529
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
|
|
|
rs104894360
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121913530
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study suggests that the combination of RAF and CDK4/6 inhibitors might be a novel treatment strategy for KRAS G12R mutant pancreatic cancer.
|
30271501 |
2018 |
rs121913530
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These effects were tested on MiaPaCa-2 human pancreatic cancer cells carrying a K-Ras activating mutation (G12C) after exposure to individual statins (20 μM).
|
29262834 |
2017 |
rs121913530
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Presence of the KRAS G12C mutation had 96% specificity and positive predictive value for lung adenocarcinoma, whereas G12R was 99% specific for pancreatic cancer with a positive predictive value of 86%.
|
23887294 |
2014 |
rs121913527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among fish injected with one of five KRAS mutations reported in other tumor types but not in human pancreatic cancer, 2/79 (2.5%) developed pancreatic tumors, with both tumors arising in fish injected with A146T.
|
25065594 |
2015 |