|
rs11542035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.
|
7706948 |
1995 |
|
rs730882087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.
|
7706948 |
1995 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Trp64Arg mutation of the beta 3-adrenergic receptor (beta 3AR) is prevalent in several ethnic groups and is associated with weight gain, and some features of syndrome X such as insulin resistance and dyslipidaemia.
|
9112025 |
1997 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit reductions in LPL activity and are predisposed to dyslipidemia and cardiovascular disease.
|
10636447 |
1999 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was a significant interaction between Asn291Ser and insulin resistance in normoglycaemic subjects, indicating that dyslipidaemia is more severe in Asn/ Ser carriers with reduced insulin sensitivity.
|
11073182 |
2000 |
|
rs11575937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
FPLD was recently discovered to result from mutated LMNA (R482Q; OMIM #150330.0010), which is the gene encoding nuclear lamins A and C. Results from extended pedigrees indicate that dyslipidemia precedes the plasma glucose abnormalities in FPLD subjects with mutant LMNA, and that the hyperinsulinemia is present early in the course of the disease.
|
11122771 |
2000 |
|
rs11575937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Through the use of focused DNA sequencing of positional candidate genes on chromosome 1q21, we discovered that FPLD results from mutations in LMNA (R482Q; OMIM 150330.0010), which is the gene that encodes nuclear lamins A and C. By stratifying members of extended FPLD pedigrees according to LMNA genotype, we found that hyperinsulinemia is present early in the course of the disease and that dyslipidemia (characterized by high triglycerides and depressed HDL cholesterol) precedes the development of glucose abnormalities.
|
11136544 |
2000 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Pro(12)Ala (P12A) variant of exon B of the peroxisome proliferator-activated receptor gamma(2) (PPAR gamma) been variably associated with obesity, insulin sensitivity, diabetes, and dyslipidemia, but its role in insulin resistance-associated traits remains uncertain.
|
11158005 |
2001 |
|
rs1801282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Pro(12)Ala (P12A) variant of exon B of the peroxisome proliferator-activated receptor gamma(2) (PPAR gamma) been variably associated with obesity, insulin sensitivity, diabetes, and dyslipidemia, but its role in insulin resistance-associated traits remains uncertain.
|
11158005 |
2001 |
|
rs1799883
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate whether or not the intestinal fatty acid binding protein gene (FABP2)-Ala54Thr variation is related to non-insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.
|
11593593 |
1999 |
|
rs773641005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate whether or not the intestinal fatty acid binding protein gene (FABP2)-Ala54Thr variation is related to non-insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.
|
11593593 |
1999 |
|
rs1799883
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children.
|
11866034 |
2001 |
|
rs1232898090
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Pro12Ala polymorphism of PPAR(gamma2) gene is not associated with diabetic retinopathy but is associated with dyslipidemia in male type 2 diabetic patients.
|
11928067 |
2002 |
|
rs80356814
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest the LMNA 1908C/T single nucleotide polymorphism (SNP) is not associated with the prevalence of type 2 diabetes, although it may be a factor predisposing to insulin resistance and dyslipidemia in some Japanese.
|
12145775 |
2002 |
|
rs1337503417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In healthy normoglycemic Finnish subjects, the K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with impaired insulin secretion or dyslipidemia.
|
12547881 |
2003 |
|
rs16139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Leu7Pro polymorphism in the signal peptide of the preproneuropeptide Y (NPY) has been associated with dyslipidemias and free fatty acid (FFA) levels during exercise.
|
12759898 |
2003 |
|
rs1800206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study was performed to evaluate the association between the PPARalpha polymorphism L162V and the presence of dyslipidemia and/or atherosclerotic disease in patients with DM-2 in comparison with nondiabetic controls.
|
15199365 |
2004 |
|
rs1799883
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia.
|
15547295 |
2005 |
|
rs773641005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia.
|
15547295 |
2005 |
|
rs80356814
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases.
|
16117820 |
2005 |
|
rs137852912
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The recent discovery of mutations in PCSK9 protein associated with low plasma low-density lipoprotein in humans, the characterization of PCSK9-deficient mice hypersensitive to statins and the severely pathological phenotype of D374Y PCSK9-mutated patients shed a new light on this gene: is it a promising therapeutic target for dyslipidemias?
|
16487721 |
2006 |
|
rs3816873
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Emerging evidence has indicated that the functional MTP exon polymorphism I128T is associated with dyslipidemia and other traits of the insulin-resistance syndrome, and the T128 variant seems to confer a reduced stability of MTP, resulting in reduced binding of LDL particles.
|
16721486 |
2006 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that the Asn291Ser variant in the LPL gene is a risk factor for dyslipidemia, characterized by hypertriglyceridemia and low HDL-C levels.
|
16741292 |
2006 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
|
17087055 |
2006 |
|
rs1800206
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition, the Leu162Val polymorphism was not associated with WHO-defined obesity or dyslipidaemia in case-control settings involving 961 obese and 2563 lean subjects and 1399 dyslipidaemic and 4399 normolipidaemic subjects, respectively.
|
17129741 |
2007 |