|
rs10054203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms exhibited prominent associations with lung cancer risk, including rs7726159 (OR = 1.34, 95%CI: 1.18-1.52, P = 7.78 × 10<sup>-6</sup> ), rs10054203 (OR = 1.29, 95%CI: 1.13-1.46, P = 1.37 × 10<sup>-4</sup> ), rs2736107 (OR = 1.28, 95%CI: 1.11-1.47, P = 5.14 × 10<sup>-4</sup> ), and rs2853677 (OR = 1.23, 95%CI: 1.08-1.39, P = 0.002).
|
30680798 |
2019 |
|
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
|
rs112290073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs138895564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs144779807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs2075786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
POT1 rs10244817, TERT rs2075786, and TERF2 rs251796 were significantly associated with lung cancer (p(trend)< or =0.05).
|
19285750 |
2009 |
|
rs2242652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that rs10936599 (<i>TERC</i>) and rs10069690, rs2242652 and rs2853677 in <i>TERT</i> and haplotype "TA" of <i>TERT</i> were revealed as risk factors of lung cancer in a Chinese Han population.
|
29299136 |
2017 |
|
rs2735940
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2735940
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.
|
25716168 |
2015 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations.
|
24761905 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT-rs2736098 T allele was also associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma.
|
24861918 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence.
|
28827732 |
2017 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results suggest that the rs2736098 polymorphism may contribute to the risk of lung cancer, especially adenocarcinoma, in the Chinese population.
|
24260099 |
2013 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer.
|
29695979 |
2018 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Additionally, the association was more significant in Asians (OR=1.20; 95% CI=1.07-1.34), while in subsequent analyses stratified by cancer type, the variant rs2736098 was definitely associated with increased lung cancer (OR=1.18; 95% CI=1.07-1.29) and hepatocellular carcinoma risk (OR=1.38; 95% CI=1.20-1.59).
|
27273963 |
2016 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
|
rs2736100
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |