|
rs237025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this hospital-based, case-control study of 519 Chinese psoriasis vulgaris patients and 541 matched controls, we genotyped the NFKB1-94 ins/delATTG and the SUMO4 rs237025 A>G polymorphisms and assessed their respective associations with psoriasis vulgaris risk.
|
18330586 |
2008 |
|
rs6887695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For both PA and PV, we detected the strongest association with two IL12B single-nucleotide polymorphisms and the corresponding haplotype as reflected by minimal P-values of 10(-7) and highest odds ratios of 1.50 (1.28-1.75) for rs6887695 in PA patients and 1.50 (1.27-1.76) for rs3212227 in the PV cohort, respectively.
|
18800148 |
2009 |
|
rs3212227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For both PA and PV, we detected the strongest association with two IL12B single-nucleotide polymorphisms and the corresponding haplotype as reflected by minimal P-values of 10(-7) and highest odds ratios of 1.50 (1.28-1.75) for rs6887695 in PA patients and 1.50 (1.27-1.76) for rs3212227 in the PV cohort, respectively.
|
18800148 |
2009 |
|
rs33980500
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
rs1800925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
rs20541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant increase of the MTHFR 677 C > T mutation in patients with psoriasis vulgaris compared with controls (χ(2) = 0.733, p = 0.392).
|
22217364 |
2012 |
|
rs27524
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In PsV a significant association was found for IL28RA (rs4649203, P = 9.53 × 10(-7)), TNIP1 (rs17728338, P = 1.21 × 10(-4)) and ERAP1 (rs27524, P = 1.17 × 10(-3)).
|
23252691 |
2013 |
|
rs17728338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In PsV a significant association was found for IL28RA (rs4649203, P = 9.53 × 10(-7)), TNIP1 (rs17728338, P = 1.21 × 10(-4)) and ERAP1 (rs27524, P = 1.17 × 10(-3)).
|
23252691 |
2013 |
|
rs4649203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In PsV a significant association was found for IL28RA (rs4649203, P = 9.53 × 10(-7)), TNIP1 (rs17728338, P = 1.21 × 10(-4)) and ERAP1 (rs27524, P = 1.17 × 10(-3)).
|
23252691 |
2013 |
|
rs6887695
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of IL-12B gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the Chinese Han population.
|
23564024 |
2013 |
|
rs3135388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics of family history in patients with psoriasis vulgaris.
|
23834030 |
2013 |
|
rs9264942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whether rs9264942 SNP is associated with PsV was investigated here. rs9264942T>C was genotyped in 292 PsV patients, and 254 controls using TaqMan Genotyping Assay.
|
24759677 |
2014 |
|
rs9264942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whether rs9264942 SNP is associated with PsV was investigated here. rs9264942T>C was genotyped in 292 PsV patients, and 254 controls using TaqMan Genotyping Assay.
|
24759677 |
2014 |
|
rs6474412
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results demonstrate that the combined effect of rs6474412-C/T polymorphism in smoking-related CHRNB3-CHRNA6 region gene and smoking behavior may not confer risk to PV, but may have impact on PV severity in Chinese Han population.
|
24792900 |
2014 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we found combined effect of rs6265 genotype (GG) and higher BMI (≥25) increased risk of PV (OR = 2.09; 95 % CI, 1.02-4.28; P < 0.05; adjusted OR = 3.19; 95 % CI, 1.37-7.45; P < 0.05) and clinically severity of PV (OR = 2.71; 95 % CI, 1.09-6.72; P < 0.05; adjusted OR = 1.25; 95 % CI, 1.10-1.40; P < 0.05).
|
25052186 |
2014 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris.
|
25052186 |
2014 |
|
rs610604
|
|
|
0.710 |
GeneticVariation |
BEFREE |
SNP rs610604 in the TNFAIP3 locus is associated with the clinical severity of PV in a Chinese Han population.
|
25496073 |
2015 |
|
rs1010824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed single nucleotide polymorphisms of ANGPT1 (rs2507800, rs1954727 and rs1010824), ANGPT2 (rs3739390, rs2442598 and rs1868554) and caspase-5 (rs507879, rs518604 and rs523104) in 343 patients with PV and 347 healthy controls (HCs) by the SNaPshot method, and evaluated the risk for psoriasis conferred by the individual polymorphisms and haplotypes.
|
25753570 |
2015 |
|
rs1868554
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed single nucleotide polymorphisms of ANGPT1 (rs2507800, rs1954727 and rs1010824), ANGPT2 (rs3739390, rs2442598 and rs1868554) and caspase-5 (rs507879, rs518604 and rs523104) in 343 patients with PV and 347 healthy controls (HCs) by the SNaPshot method, and evaluated the risk for psoriasis conferred by the individual polymorphisms and haplotypes.
|
25753570 |
2015 |
|
rs2442598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2442598 polymorphism of ANGPT2 was significantly associated with PV.
|
25753570 |
2015 |
|
rs3739390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the distribution of the other genotypes (rs2507800, rs1954727 and rs1010824 of ANGPT1; rs3739390 and rs1868554 of ANGPT2; and rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with PV and the HCs.
|
25753570 |
2015 |
|
rs518604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed single nucleotide polymorphisms of ANGPT1 (rs2507800, rs1954727 and rs1010824), ANGPT2 (rs3739390, rs2442598 and rs1868554) and caspase-5 (rs507879, rs518604 and rs523104) in 343 patients with PV and 347 healthy controls (HCs) by the SNaPshot method, and evaluated the risk for psoriasis conferred by the individual polymorphisms and haplotypes.
|
25753570 |
2015 |
|
rs523104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the distribution of the other genotypes (rs2507800, rs1954727 and rs1010824 of ANGPT1; rs3739390 and rs1868554 of ANGPT2; and rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with PV and the HCs.
|
25753570 |
2015 |
|
rs72474224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population.
|
26104599 |
2015 |