| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.040 | GeneticVariation | BEFREE | We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis. | 30939298 | 2019 |
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|
0.040 | GeneticVariation | BEFREE | This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population. | 29783069 | 2018 |
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|
0.040 | GeneticVariation | BEFREE | In conclusion, literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. | 30142580 | 2018 |
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|
0.040 | GeneticVariation | BEFREE | Although the present results do not support that IL-1B (rs1143634) SNP could be identified as a risk predictor for CP in the present population, the synergistic interaction of the CT/CC genotypes of NLRP3 (rs4612666) SNP with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease. | 26854620 | 2016 |
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|
0.030 | GeneticVariation | BEFREE | We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis. | 30939298 | 2019 |
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|
0.030 | GeneticVariation | BEFREE | The subgroup analysis stratified by ethnicity showed a weak association between the IL-1<i>β</i> polymorphism (rs16944</span>) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017-1.758, <i>P</i> = 0.037). | 30647799 | 2018 |
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|
0.030 | GeneticVariation | BEFREE | Seventy-four patients with VD of whom 36 had CP were genotyped for single nucleotide polymorphisms in the IL1A -889 (rs1800587), IL1B +3954 (rs1143634) and IL1B at -511 (rs16944) genes and for VNTR polymorphisms in the IL1RN gene. | 24612355 | 2014 |
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|
0.010 | GeneticVariation | BEFREE | We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis. | 30939298 | 2019 |