|
rs9823696
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
The locus identified near HTR3C and ABCC5 (rs9823696) was associated specifically with oesophageal adenocarcinoma (p=1·6 × 10<sup>-8</sup>) and was independent of Barrett's oesophagus development (p=0·45).
|
27527254 |
2016 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A148T mutation were found in 3% (1/33) patients with GM, 22% (6/27) - IM, 25% (2/8) - dysplasia and 27% patients with ADC (3/11).
|
22440936 |
2012 |
|
rs11941492
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs2445762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs696217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs4740363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs2236302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs11775256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs17757541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs4661636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs of rs3127075 in Caspase-7 (CASP7) and rs4661636 in Caspase-9 (CASP9) genes that play a critical role in apoptosis were found to be associated with an increased risk of EA.
|
20453000 |
2010 |
|
rs3127075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs of rs3127075 in Caspase-7 (CASP7) and rs4661636 in Caspase-9 (CASP9) genes that play a critical role in apoptosis were found to be associated with an increased risk of EA.
|
20453000 |
2010 |
|
rs13181
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significantly reduced frequencies were seen for the XPD Lys751Gln homozygous variant genotype in patients with EADC (OR = 0.24; 95% CI = 0.07-0.88), and for the XRCC1 Arg399Gln homozygous variant genotype in patients with BE (OR = 0.38; 95% CI = 0.12-0.64) and GERD (OR = 0.29; 95% CI = 0.12-0.66).
|
15878910 |
2005 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.
|
19302219 |
2010 |
|
rs1131691014
|
|
|
0.030 |
GeneticVariation |
BEFREE |
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.
|
19302219 |
2010 |
|
rs878854066
|
|
|
0.030 |
GeneticVariation |
BEFREE |
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.
|
19302219 |
2010 |
|
rs1353702185
|
|
|
0.020 |
GeneticVariation |
BEFREE |
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.
|
19302219 |
2010 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TNF-α-308 G>A (rs1800629) is not significantly associated with a risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma.
|
27821804 |
2016 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that the ERCC2 Asp312Asn polymorphism might be associated with increased risk of esophageal adenocarcinoma and a protective factor for esophageal squamous cell carcinoma.
|
24234258 |
2014 |
|
rs2294008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of interest, the association of rs2294008 with ESCC was consistent with that observed in esophageal adenocarcinoma and ESCC in Caucasian populations.
|
24654646 |
2014 |
|
rs766958673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant difference in MTR A2756G genotype distribution was observed between controls (A/A 66.9%, A/G 29.8%, G/G 3.3%) and patients with ESCC (A/A 61.7%, A/G 36.3%, G/G 2.1%), BC (A/A 69.2%, A/G 26.9%, G/G 3.9%), CC (A/A 51.8%, A/G 44.6%, G/G 3.6%), or GC (A/A 73.4%, A/G 20.9%, G/G 5.7%).
|
17726616 |
2008 |
|
rs3784262
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87-0.93; P = 3.72 × 10(-9)).
|
25447851 |
2015 |
|
rs17002540
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.
|
29551738 |
2018 |
|
rs2434584
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.
|
29551738 |
2018 |
|
rs2971030
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.
|
29551738 |
2018 |
|
rs7141987
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.
|
29551738 |
2018 |