|
rs11813268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10<sup>-10</sup>), 3p22.1 (rs67311347, P=2.5 × 10<sup>-8</sup>), 3q26.2 (rs10936602, P=8.8 × 10<sup>-9</sup>), 8p21.3 (rs2241261, P=5.8 × 10<sup>-9</sup>), 10q24.33-q25.1 (rs11813268, P=3.9 × 10<sup>-8</sup>), 11q22.3 (rs74911261, P=2.1 × 10<sup>-10</sup>) and 14q24.2 (rs4903064, P=2.2 × 10<sup>-24</sup>).
|
28598434 |
2017 |
|
rs132793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs1417080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, a 2-stage case-control study was performed to evaluate the association between 2 tagging SNPs (rs1417080 and rs7859384) and RCC susceptibility.
|
31038847 |
2019 |
|
rs3118523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Across RXRA, one haplotype located 3' of the coding sequence (rs748964, rs3118523), increased RCC risk 35% among individuals with the variant haplotype compared to those with the most common haplotype.
|
19753122 |
2009 |
|
rs6466135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a three-phase design with a total of 2657 RCC cases and 5315 healthy controls, two single nucleotide polymorphisms (SNPs) that map to PIK3CG (rs6466135:A, ORmeta = 0.85, 95% CI = 0.77-0.94, Pmeta = 1.4 × 10-3) and ATM (rs611646:T, ORmeta = 1.17, 95% CI = 1.05-1.31, Pmeta = 3.5 × 10-3) were significantly associated with RCC risk.
|
29635281 |
2018 |
|
rs7132434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the RCC risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family.
|
27384883 |
2016 |
|
rs748964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Across RXRA, one haplotype located 3' of the coding sequence (rs748964, rs3118523), increased RCC risk 35% among individuals with the variant haplotype compared to those with the most common haplotype.
|
19753122 |
2009 |
|
rs7859384
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that rs7859384 of lncARSR was associated with RCC susceptibility and may act as a prognostic biomarker for patients with RCC.
|
31038847 |
2019 |
|
rs2231142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers with the C/C genotype of the BCRP C421A polymorphism are at risk of developing nonpapillary RCC.
|
15906349 |
2005 |
|
rs1154454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed effect modification by variation in rs1154454 (ADH7) (p<sub>interaction</sub> = 0.007); a per unit increase in alcohol drink/day was associated with 35% lower RCC risk among non-minor allele carriers, a 27% lower risk among those who carry one copy of the minor allele, but no association was observed among those with two copies of the minor allele.
|
29023769 |
2018 |
|
rs182052
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that ADIPOQ rs182052 is significantly associated with cc</span>RCC risk.
|
25827778 |
2015 |
|
rs182052
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study found significant combined effects of obesity and the ADIPOQ rs182052 G/A+A/A genotype on the arsenic-related risk of RCC in a population with low arsenic exposure.
|
29723618 |
2018 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined the frequency of single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in the adiponectin gene (ADIPOQ) in 1004 patients with clear cell renal cell carcinoma (ccRCC) compared with a group of healthy subjects (n = 1108).
|
25827778 |
2015 |
|
rs3774262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined the frequency of single nucleotide polymorphisms (rs182052G>A, rs266729C>G, and rs3774262G>A) in the adiponectin gene (ADIPOQ) in 1004 patients with clear cell renal cell carcinoma (ccRCC) compared with a group of healthy subjects (n = 1108).
|
25827778 |
2015 |
|
rs1800435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant modification in RCC risk was observed for the functional variant rs1800435(K68N).
|
21799727 |
2011 |
|
rs2761016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Joint effects of lead and ALAD rs2761016 suggest an increased RCC risk for the homozygous wild-type and heterozygous alleles ((GG)OR = 2.68, 95%CI = 1.17-6.12, p = 0.01; (GA)OR = 1.79, 95%CI = 1.06-3.04 with an interaction approaching significance (p(int) = 0.06).
|
21799727 |
2011 |
|
rs1048798213
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PBRM1 p.L641V was detected in the plasma sample of the ccRCC patient with an allele frequency of 0.2%.
|
30986100 |
2019 |
|
rs1442780982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PBRM1 p.L641V was detected in the plasma sample of the ccRCC patient with an allele frequency of 0.2%.
|
30986100 |
2019 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control study of 612 RCC patients and 632 age and sex matched healthy controls, we genotyped two APE1 functional polymorphisms (-656 T>G, rs1760944 and 1349 T>G, rs1130409) and assessed their associations with risk of RCC.
|
21538578 |
2011 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a case-control study of 612 RCC patients and 632 age and sex matched healthy controls, we genotyped two APE1 functional polymorphisms (-656 T>G, rs1760944 and 1349 T>G, rs1130409) and assessed their associations with risk of RCC.
|
21538578 |
2011 |
|
rs405509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study was designed to explore the association of renal cell carcinoma (RCC) with VHL (rs779805), MTHFR (rs1801133) and APOE (rs8106822 and rs405509) polymorphisms, investigate the interactions among the single nucleotide polymorphisms (SNPs), and explore roles of the interactions in the pathogenesis of RCC in Chinese Han population.
|
26191297 |
2015 |
|
rs2606736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicated that ATG7 polymorphisms (rs2606736 and rs6442260) have a protective role for ccRCC risk.
|
30827239 |
2019 |
|
rs6442260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicated that ATG7 polymorphisms (rs2606736 and rs6442260) have a protective role for ccRCC risk.
|
30827239 |
2019 |
|
rs611646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a three-phase design with a total of 2657 RCC cases and 5315 healthy controls, two single nucleotide polymorphisms (SNPs) that map to PIK3CG (rs6466135:A, ORmeta = 0.85, 95% CI = 0.77-0.94, Pmeta = 1.4 × 10-3) and ATM (rs611646:T, ORmeta = 1.17, 95% CI = 1.05-1.31, Pmeta = 3.5 × 10-3) were significantly associated with RCC risk.
|
29635281 |
2018 |
|
rs750597831
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk relevance of the P81S von Hippel-Lindau (VHL) gene hotspot mutation identified in clear cell renal cell carcinoma from individuals exposed occupationally to trichloroethylene (TCE) is not known.
|
23990666 |
2013 |