|
rs2294008
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system.
|
26706772 |
2016 |
|
rs2294008
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03-2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13-1.98 for the dominant model).
|
24023815 |
2013 |
|
rs11730059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004).
|
28685609 |
2017 |
|
rs11730582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004).
|
28685609 |
2017 |
|
rs13361707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, three SNPs, MUC1 rs4072037, ZBTB20 rs9841504 and PRKAA1 rs13361707, were associated with precancerous gastric lesions (severe IM/dysplasia).
|
28220687 |
2017 |
|
rs2853744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004).
|
28685609 |
2017 |
|
rs4072037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, three SNPs, MUC1 rs4072037, ZBTB20 rs9841504 and PRKAA1 rs13361707, were associated with precancerous gastric lesions (severe IM/dysplasia).
|
28220687 |
2017 |
|
rs6833161
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004).
|
28685609 |
2017 |
|
rs9841504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, three SNPs, MUC1 rs4072037, ZBTB20 rs9841504 and PRKAA1 rs13361707, were associated with precancerous gastric lesions (severe IM/dysplasia).
|
28220687 |
2017 |
|
rs1179251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, elevated risks of CAG (OR = 2.64, 95 % CI 1.89-3.69), intestinal metaplasia (IM; OR = 5.58, 95 % CI 3.86-8.05), and dysplasia (DYS; OR = 1.64, 95 % CI 1.18-2.26) were observed in subjects with IL-22 rs1179251 CC genotype.
|
26358252 |
2016 |
|
rs2709800
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NOD1 rs2709800 TG genotype carriers had a decreased risk of intestinal metaplasia (IM, OR: 0.53; 95% CI: 0.31-0.92), while NOD2 rs718226 G allele (AG/GG) showed increased risks of dysplasia (DYS, OR: 2.96; 95% CI: 1.86-4.71) and GC (OR: 2.35; 95% CI: 1.24-4.46).
|
25933107 |
2015 |
|
rs4833095
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
rs718226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NOD1 rs2709800 TG genotype carriers had a decreased risk of intestinal metaplasia (IM, OR: 0.53; 95% CI: 0.31-0.92), while NOD2 rs718226 G allele (AG/GG) showed increased risks of dysplasia (DYS, OR: 2.96; 95% CI: 1.86-4.71) and GC (OR: 2.35; 95% CI: 1.24-4.46).
|
25933107 |
2015 |
|
rs1042194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs10505799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164</span> CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03-1.97] and dysplasia (OR, 1.54; 95% CI, 1.05-2.25) compared to GG carriers, whereas no significant association was observed for rs895819.
|
23613822 |
2013 |
|
rs6878265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs895819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164 CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03-1.97] and dysplasia (OR, 1.54; 95% CI, 1.05-2.25) compared to GG carriers, whereas no significant association was observed for rs895819.
|
23613822 |
2013 |
|
rs199907548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have detected the I49S mutation in 12% (4/33) patients with GM, 18% (5/27) with IM, 50% - with dysplasia (4/8) and in 27% (3/11) - with ADC.
|
22440936 |
2012 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A148T mutation were found in 3% (1/33) patients with GM, 22% (6/27) - IM, 25% (2/8) - dysplasia and 27% patients with ADC (3/11).
|
22440936 |
2012 |
|
rs121912664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node).
|
22004116 |
2011 |
|
rs2066842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This paper shows analysis of the association of the 802C>T polymorphism of the NOD2/CARD15 gene with the occurrence of the chronic inflammation of the gastric mucosa associated with the Helicobacter pylori infections, development of intestinal metaplasia and dysplasia and, in the result of this, gastric cancer.
|
20230816 |
2010 |
|
rs2075820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that carriage of the NOD1 G796A mutation increases the susceptibility of gastric epithelial cells for intestinal metaplasia and atrophy when infected by CagA-positive Helicobacter pylori strains.
|
19882212 |
2010 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score.
|
17171451 |
2007 |
|
rs771184127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score.
|
17171451 |
2007 |